5-HT3受体拮抗剂盐酸阿扎司琼的合成
Synthesis of the 5-HT3 Receptor Antagonist Azasetron Hydrochloride
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摘要: 目的：改进5-HT3受体拮抗剂盐酸阿扎司琼的合成工艺。方法：以5-氯-2-羟基苯甲酸甲酯为原料，经硝化、还原等九步反应合成。结果：合成了目标化合物，总收率为40％，其结构经IR，^1HNMR和MS确证。结论：合成路线及工艺较适合于工业化生产。Abstract: AIM:The purpose is to develop the general process for the synthesis of 5-HT 3 receptor antagonist Azasetron Hydrochloride. METHOD: It was synthesized from methyl 5-chloro-2-hydroxyl benzoic acid via nine-step reaction with nitration,reduction,etc. RESU
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