微泡型口腔速释片的制备

Preparation of Micro-effervescing Fast-release Oral Tablet

摘要: 目的：制备微泡型口腔速释片。方法：采用自制的“微量吸水测定装置”测定片剂吸水速率及时滞，结合口腔内崩解时间及口感，对速释片的处方及工艺进行筛选。结果：粘合剂PVPK30水溶液的浓度对片剂的吸水过程影响较小，MCC的最佳用量为10％，8％的PVPP作为内加崩解剂效果最好，外加泡腾崩解剂的最佳用量为2％。结论：本速释片处方及制备工艺简单，在口腔内8s即完全崩解，口感良好。

Abstract: AIM:To develop the micro-effervescing fast-release oral tablet. METHOD:The formulation and technology of the fast-release tablet were evaluated with the self-made apparatus for measurement of water uptake rate and lag time, combined with consideration of