应用卡波姆971PNF制备胃内漂浮型缓释片及其体外评价

Preparation and in vitro Evaluation of Gastric Floating and Sustained-release Tablets Using Carbopol 971PNF

摘要: 目的：研制以卡波姆971PNF为骨架材料的新型胃内漂浮型缓释片。方法：分别以诺氟沙星和盐酸二甲双胍为难溶性和易溶性模型药物，以卡波姆971PNF和碳酸氢钠为主要辅料制成胃内漂浮型缓释片，转篮法测定了漂浮片的释放度并检测其漂浮性能：结果：卡波姆971PNF含量在10％，左右时，对诺氟沙星有明显的缓释作用，碳酸氢钠对释放速率有影响，随着卡波姆971PNF含量的增加，诺氟沙星趋向于零级释放：卡波姆971PNF含量在20％，左右时，对盐酸二甲双胍有明显的缓释作用，碳酸氢钠对释放速率影响不明显，其体外释放行为符合ITiguchi方程。卡波姆971PNF及碳酸氢钠均对漂浮性能有影响，而硬度对漂浮性能影响小结论：以卡波姆971PNF制备的胃内漂浮型缓释片具有起漂快，漂浮时间长，缓释效果好，制备工艺简单等优点
- 诺氟沙星 /
- 盐酸二甲双胍 /
- 胃内漂浮型缓释片 /
- 卡波姆971PNF
Abstract: AIM:To develop a novel gastric floating sustained-release tablet using Carbopol 971PNF as matrix material. METHOD:The tablets containing Carbopol 971PNF and sodium bicarbonate as main excipients,and norfloxacin and metformin hydrochloride as an insoluble
- Norfloxacin /
- Metformin hydrochloride /
- Gastric floating sustained-release tablets /
- Carbopol 971PNF