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应用卡波姆971PNF制备胃内漂浮型缓释片及其体外评价

Preparation and in vitro Evaluation of Gastric Floating and Sustained-release Tablets Using Carbopol 971PNF

  • 摘要: 目的:研制以卡波姆971PNF为骨架材料的新型胃内漂浮型缓释片。方法:分别以诺氟沙星和盐酸二甲双胍为难溶性和易溶性模型药物,以卡波姆971PNF和碳酸氢钠为主要辅料制成胃内漂浮型缓释片,转篮法测定了漂浮片的释放度并检测其漂浮性能:结果:卡波姆971PNF含量在10%,左右时,对诺氟沙星有明显的缓释作用,碳酸氢钠对释放速率有影响,随着卡波姆971PNF含量的增加,诺氟沙星趋向于零级释放:卡波姆971PNF含量在20%,左右时,对盐酸二甲双胍有明显的缓释作用,碳酸氢钠对释放速率影响不明显,其体外释放行为符合ITiguchi方程。卡波姆971PNF及碳酸氢钠均对漂浮性能有影响,而硬度对漂浮性能影响小结论:以卡波姆971PNF制备的胃内漂浮型缓释片具有起漂快,漂浮时间长,缓释效果好,制备工艺简单等优点

     

    Abstract: AIM:To develop a novel gastric floating sustained-release tablet using Carbopol 971PNF as matrix material. METHOD:The tablets containing Carbopol 971PNF and sodium bicarbonate as main excipients,and norfloxacin and metformin hydrochloride as an insoluble

     

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