新型肝靶向载体N-乳糖酰化壳聚糖的制备与表征

基金项目: 国家“973”重点基础研究发展规划项目基金资助 (编号G19990 64 70 5 )~~

Preparation and Characterization of Novel Galactosylated Chitosan

摘要: 目的：将肝靶向基团半乳糖基引入到壳聚糖的结构中，制备N-乳糖酰化壳聚糖。方法：以天然聚合物壳聚糖为原料，在其2-NH2引入乳糖酸，制得酰化产物，用FTIR、^13CNMR,^1HNMR时其进行表征。用粉末X衍射、DSC、TG对其物理性质进行分析。结果与结论：制得了新型的取代度为20%的N-取代的乳糖酰化壳聚糖载体。
- 壳聚糖 /
- 乳糖 /
- 肝靶向 /
- 载体 /
- 制备 /
- 表征
Abstract: AIM: To prepare galactosylated chitosan as hepatocyte-targeting carrier. METHOD: By using galactosylated group introduced into the amino group of chitosan,galactosylated chitosan was synthesized. The chemical structure of galactosylated chitosan was chara
- Chitosan /
- Lactose /
- Hepatocyte-targeting /
- Preparation /
- Carrier /
- Characterization