溴芬酸钠的合成

Synthesis of Bromfenac Sodium

摘要: 目的：对专利合成溴芬酸钠路线进行改进。方法：以对溴苯甲腈和吲哚啉为原料，经硫化、氧化、氯化、酸水解、碱水解开环生成溴芬酸钠。结果：总收率为28．8％。结论：工艺适合于生产。
- 溴芬酸钠 /
- 非甾体抗炎药 /
- 镇痛 /
- 对溴苯甲腈 /
- 吲哚啉 /
- 合成
Abstract: AIM:To develope the synthesis route of bromfenac.METHOD:Bromfenac sodium was prepared from p -bromobenzonitrile and indoline.RESULT:The total yield was 28.8%. CONCLUSION:This synthesis route is applicable for large sale production.
- NSAID analgesic /
- Bromfenac sodium /
- p -bromobenzonitrile /
- Indoline /
- Synthesis