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溴芬酸钠的合成

Synthesis of Bromfenac Sodium

  • 摘要: 目的:对专利合成溴芬酸钠路线进行改进。方法:以对溴苯甲腈和吲哚啉为原料,经硫化、氧化、氯化、酸水解、碱水解开环生成溴芬酸钠。结果:总收率为28.8%。结论:工艺适合于生产。

     

    Abstract: AIM:To develope the synthesis route of bromfenac.METHOD:Bromfenac sodium was prepared from p -bromobenzonitrile and indoline.RESULT:The total yield was 28.8%. CONCLUSION:This synthesis route is applicable for large sale production.

     

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