海藻酸微球及骨架片中苯基偶氮苯的释放特性

Release Characteristics of 4-Phenylazoaniline From Alginate Microparticles and Matrix Tablets

摘要: 目的：研究海藻酸微球及由海藻酸微球、果胶、HPMC组成的骨架片中苯基偶氮苯的释放特性。方法：海藻酸微球通过喷雾-凝聚法制得，苯基偶氮苯(PAA)作为疏水性模型药物通过吸附法被微球载运。制备了由海藻酸微球、果胶、HPMC组成的骨架片。测定了海藻酸微球及骨架片中苯基偶氮苯的释放。为进一步探讨药物释放机制，进行了骨架片的溶胀实验。结果：微球中PAA的释放依赖于释放介质，其中在水中释放不完全，在人工胃肠液中呈延缓到肠内释放的特性。在骨架片中也观察在人工胃肠液中的延缓释放行为。果胶酶有一定的加速骨架片释放的的作用。释放度和溶胀实验数据均证明骨架片为溶胀控制。结论：海藻酸微球可以作为一种疏水性药物的延缓释放载药系统。
- 海藻酸微球 /
- 骨架片 /
- 苯基偶氮苯 /
- 溶胀 /
- 体外释放
Abstract: AIM:To investigate the release cha racteristics of insoluble drug from algi nate macroparticles and matrix tablets METHOD:Alginate micropar ti cles were manufactured by spray-coagulation method 4-phenylazoaniline (PAA) wa s selected as a insoluble mode
- Alginate microparticles /
- Matrix tablets /
- 4-phenyla zoaniline /
- Swelling experiment /
- \%in vitro\% release