(3R,4R,5S)-4,5-环氧基-3-(1-乙基丙氧基)-1-环己烯-1-甲酸乙酯的合成

Synthesis of Ethyl(3R,4R,5S)-4,5-epoxy-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

摘要: 目的：(3R，4R，5S)-4，5-环氧基-3-(1-乙基丙氧基)-1-环己烯-1-甲酸乙酯是合成抗流感病毒新药奥塞米韦的关键中间体，本文对其不对称合成方法进行研究和改进。方法：以(-)莽草酸为起始物，经酯化、转酮化、还原开环、环氧化等6步反应生成立体专一的目标产物。结果：产物的化学结构经FT-IR，^1HNMR和^13CNMR得以确证。结论：本方法较文献方法反应条件温和，产率提高且成本降低。

Abstract: AIM:Ethyl(3R,4R,5S)-4,5-epox y-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate is a key intermediate f or the preparation of novel anti-influenza drug oseltamivir and this study is to improve the chiral synthetic procedure of i t. METHOD:Title compound was