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萘丁美酮的合成工艺改进

Improved Synthetic Process of Nabumetone

  • 摘要: 萘丁美酮(nabumetone)是英国Beecham公司开发的一种长效非甾体抗炎镇痛药1,具有很强抗炎活性,口服易吸收,而且胃肠道刺激小,不良反应少,耐受性好2.

     

    Abstract: AIM:To enhance the yield of Nabumeton e,and to improve the previous synthetic method METHOD: Nabumetone is prepared with cheap reagen ts via only three steps RESULT: The cost is reduced and th e yield is increased by 2184% in the suggested method Therefor

     

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