微乳对难溶性药物增溶机理的研究

Study on the Mechanism of Lipophilic Drugs Incorporation into Microemulsion System

摘要: 目的:初步探讨微乳对难溶性药物的增溶机理.方法:经处方筛选及相图研究确定(BL-9/正丁醇3∶1)/油/水比例为9∶1∶40的微乳处方;以二氢吡啶类药物为模型药物,测定其在微乳、胶束和油相中的溶解度及油/水分配系数;根据化学结构,采用计算机软件计算药物的特性参数,并结合模型药物的特性分析微乳增溶难溶性药物的机理.结果:微乳对药物的增溶效果远大于油相和胶束,并随药物的脂溶性和空间结构的改变而变化.结论:微乳可用于增溶难溶性药物,且脂溶性越大,空间位阻越小,增溶效果越明显.
- 二氢吡啶类药物 /
- 微乳 /
- 油/水分配系数 /
- 脂溶性 /
- 空间位阻
Abstract: AIM:To study the mechanism of lipophilic drugs incorporation into O/W microemulsion system.METHOD:The formulation of microemulsion was optimized based on the results of the pseudo-termary phase diagram.The oil/water partition coefficient and the solubilit
- Dihydropyridines drugs /
- Microemulsion /
- Oil/water partition coefficent /
- Lipophilic /
- Space structure