灯盏花素前体纳米脂质体的质量评价
Quality Evaluation of Breviscapine Pre-nanoliposome
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摘要: 目的:研究灯盏花素前体纳米脂质体的性质,建立其质量评价方法.方法:考察了该脂质体的形态、粒径分布、多分散系数、Zeta电位、含量、pH值、包封率、稳定常数Ke、沉降稳定性、血管刺激性及溶血毒性.结果:灯盏花素纳米脂质体的平均粒径为20.2 nm,多分散系数为0.552,Zeta电位为-74.5 mV,包封率均大于70%,稳定性较好,可安全用于静脉给药.结论:上述方法适用于灯盏花素前体纳米脂质体的质量评价,可有效地反映该脂质体的性质.Abstract: AIM:To study various properties of pre-nanoliposomes and to establish quality evaluation methods. METHOD:The form of the nanoliposome was observed with transmission electron microgram and the particles size,polydispersity,Zeta potential,entrapment efficie
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