Abstract: AIM:To develop the general route for the synthesis of gefitinib.METHOD: 2-Amino-4,5-dimethoxybenzoic acid was cyclized,monodemethylated,acetylated,ammoniated and chlorinated to obtain the target compound.RESULT:The structure was confirmed by elemental analysis, IR and 1H NMR.CONCLUSION:Synthetic route and methods is feasible for the preparation of gefitinib.