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一氧化氮供体型联苯双酯衍生物ZK14对大鼠肝纤维化的治疗作用

Therapeutic effects of ZK14,a novel nitric oxide donating biphenyldicarboxylate derivative,on hepatic fibrosis in rats

  • 摘要: 目的 : 研究新型一氧化氮供体型联苯双酯衍生物(ZK14)对大鼠肝纤维化的治疗作用。 方法 : 腹腔注射CCl4制备大鼠肝纤维化模型,ZK14以20 mg/kg及10 mg/kg剂量给大鼠连续灌胃给药4周,观察对大鼠血液一氧化氮、肝组织一氧化氮合酶、肝功能生化指标、肝纤维化生化指标、肝病理组织学的影响。 结果 : 与肝纤维化模型组相比,ZK14(20 mg/kg)对大鼠的肝纤维化指标和肝脏病理分级有明显改善作用,并对肝功能有保护作用。 结论 : 一氧化氮供体型联苯双酯衍生物ZK14对CCl4诱导的大鼠早期肝纤维化有较好的治疗作用。

     

    Abstract: Aim :To study the therapeutic effects of ZK14,a novel nitric oxide donor,on hepatic fibrosis in rats. Methods :Rats were injected intraperitoneally with CCl4 and induced to hepatic fibrosis,followed by intragasrtic administration with high dose of 20 mg/kg and low dose of 10 mg/kg of ZK14for 4 weeks.The effects were evaluated in the content of nitric oxide of serum and nitric oxide synthases of liver,in serum levels of the hepatic functions indices and hepatic fibrotic index and in liver histopathology. Results :The biochemical indices and pathology grade were effectively improved in the group of ZK14 20 mg/kg,and liver function was also effectively protected in this group. Conclusion :ZK14,a novel nitric oxide donating biphenyldicarboxylate derivative,showed preferable therapeutic effects on hepatic fibrosis of rats induced with CCl4,and it may be of potential value in the treatment of hepatic fibrosis.

     

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