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双氯芬酸钠层状双金属氢氧化物纳米复合物的制备及性质研究

Preparation and characterization of diclofenac sodium layered double hydroxide nanohybrids

  • 摘要: 目的 : 制备双氯芬酸钠-层状双金属氢氧化物(DS-LDH)纳米复合物并考察其性质。 方法 : 采用共沉淀法将双氯芬酸钠插入层状双金属氢氧化物(LDH)层间。通过激光粒度仪、XRD、IR、TEM等手段对纳米复合物进行表征。采用桨法考察了复合物在不同介质中的释药特征。通过二甲苯致小鼠耳肿胀实验比较了DS和DS-LDH的抗炎活性。 结果 : DS阴离子可取代层间的酸根离子形成DS-LDH纳米复合物,具有一定缓释特性。Zn-Al-NO3-LDH具有近中性pH,更适合作为眼用制剂的药物载体。DS与LDH形成纳米复合物后,不影响其抗炎活性。 结论 : 层状双金属氢氧化物可以用作为阴离子药物的缓释载体,成功制备的新型的双氯芬酸钠-无机纳米复合物具有潜在的临床应用价值。

     

    Abstract: Aim :To prepare diclofenac sodium-layered double hydroxide nanohybrids(DS-LDH) and investigate its properties. Methods :The diclofenac sodium anions were hybridized with LDH by co-precipitation.The synthetic nanohybrids were characterized by various methods,such as laser particle sizer,XRD,IR,and TEM.Paddle method according to the Chinese Pharmacopoeia was used to determine the dissolution.The anti-inflammation of nanohybrids and diclofenac sodium were compared by the effect on auricular tumescence induced by xylene in mice. Results :The acidic negative ion of layered double hydroxides were replaced by the diclofenac anion to form DS-LDH.Release studies showed that the nanohybrids could serve as controlled release systems for DS.Zn-Al-NO3-LDH was proved to have character of neutral pH which is more suitable for orphthalmic preparation.The DS-LDH nanohybrids could keep the effect of anti-inflammation. Conclusion :Layered double hydroxide nanohybrids can be used as sustained-release carrier of anionic drugs.A novel type of drug-inorganic nanohybrids was prepared successfully which has a potential value of clinical application.

     

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