N-辛基-N′-亚胺基-O-羧甲基壳聚糖衍生物的合成、表征与体外pH敏感性

基金项目: 教育部科学技术研究重点资助项目(No.107062)；教育部新世纪人才基金资助项目(No.NCET-06-0499)

Synthesis，characterization and pH sensitivity of N-octyl-N′-imino-O-carboxymethyl chitosan derivatives

摘要: 目的：以pH敏感的亚胺键为连接臂，制备两亲性羧甲基壳聚糖衍生物。方法：以羧甲基壳聚糖为原料，在其2-NH₂上引入亚胺键，制得羧甲基壳聚糖希夫碱衍生物，用FT-IR和¹H NMR对其结构进行了表征，用DSC对其物理性质进行了分析，采用紫外-可见分光光度法评价其体外pH敏感性。 结果与结论 ：合成了4个pH敏感的N-辛基-N′-亚胺基-O-羧甲基壳聚糖衍生物，以期作为肿瘤细胞溶酶体敏感的难溶性药物载体材料。
- 羧甲基壳聚糖 /
- 亚胺 /
- 聚合物胶束 /
- 溶酶体 /
- pH敏感性
Abstract: Aim ：To synthesize a series of amphiphilic carboxymethyl chitosan derivatives using pH-sensitive imines as the spacers. Methods ：Taking advantage of the imine groups introduced into carboxymethyl chitosan，schiff base derivatived carboxymethyl chitosan were synthesized.The chemical structures of galactosylated chitosan derivatives were characterized by FT-IR and ¹H NMR.Their physical properties were measured by DSC. Results and Conclusion ：Four pH-sensitive N-octyl-N′-imino-O-carboxymethyl chitosan derivatives were synthesized as potential new drug delivery agents.
- carboxymethyl chitosan /
- imine /
- polymeric micelles /
- lysosome /
- pH-sensitivity