Abstract:
Aim :To synthesize a series of amphiphilic carboxymethyl chitosan derivatives using pH-sensitive imines as the spacers.
Methods :Taking advantage of the imine groups introduced into carboxymethyl chitosan,schiff base derivatived carboxymethyl chitosan were synthesized.The chemical structures of galactosylated chitosan derivatives were characterized by FT-IR and
1H NMR.Their physical properties were measured by DSC.
Results and
Conclusion :Four pH-sensitive
N-octyl-
N′-imino-
O-carboxymethyl chitosan derivatives were synthesized as potential new drug delivery agents.