Abstract:
Aim :Synthesized
N-acylated chitosan(NAC) was used to anchor on the surface of plain docetaxel liposomes(PDL) in order to to sustain drug release.
Methods ;NAC of low substitution degrees were prepared using hexanoic(C
6),lauric(C
12),and palmitic(C
16) anhydrides.
N-palmitoyl chitosan was chosen to anchor the docetaxel liposomes.
In vitro release profiles of conventional liposmes and the anchored liposomes was compared.
Results :Hexanoic(C
6),lauric(C
12),and palmitic(C
16)-branched chitosans were synthesized.It was found that
N-acylated chitosan-anchored DXL liposomes(NDL) increase stabilities of docetaxel liposomes.70% of docetaxel was released from PDL in 24 hours but 39% from NDL.
Conclusion :Liposomes anchored by the low substituted
N/-acylated chitosan could decrease the drug release.