N-酰化壳聚糖的合成及其修饰多西他赛脂质体的体外性质研究
Synthesis of N-acyl chitosan derivatives and investigation of chitosan-modified docetaxel liposomes in vitro
-
摘要: 目的 ： 合成N-酰化壳聚糖并用其修饰多西他赛脂质体以期延缓药物的释放。 方法 ： 用合成的长链脂肪酸酰化的壳聚糖修饰脂质体，体外血浆释放实验比较脂质体修饰前后的释放性质。 结果 ： 合成了正己酰（C6）、月桂酰（C12）和棕榈酰（C16）3种N-酰化壳聚糖。普通脂质体于24 h内释药70%，而N-酰化壳聚糖修饰的脂质体24 h仅释药39%。 结论 ： 用N-酰化壳聚糖修饰脂质体可以减缓释药，具有缓释作用。Abstract: Aim ：Synthesized N-acylated chitosan(NAC) was used to anchor on the surface of plain docetaxel liposomes(PDL) in order to to sustain drug release. Methods ；NAC of low substitution degrees were prepared using hexanoic(C6)，lauric(C12)，and palmitic(C16) anhydrides.N-palmitoyl chitosan was chosen to anchor the docetaxel liposomes.In vitro release profiles of conventional liposmes and the anchored liposomes was compared. Results ：Hexanoic(C6)，lauric(C12)，and palmitic(C16)-branched chitosans were synthesized.It was found that N-acylated chitosan-anchored DXL liposomes(NDL) increase stabilities of docetaxel liposomes.70% of docetaxel was released from PDL in 24 hours but 39% from NDL. Conclusion ：Liposomes anchored by the low substituted N/-acylated chitosan could decrease the drug release.
-
Keywords:
- N-acyl chitosan /
- docetaxel /
- liposome /
- release
-
计量
- 文章访问数: 1404
- HTML全文浏览量: 0
- PDF下载量: 1530
下载:
