药物膜通透性体外评价方法研究进展

基金项目: 国家自然科学基金资助项目(No.30901878)

Development of in-vitro evaluation methods to access membrane permeability of drugs

摘要: 药物膜通透性是影响药物安全性和有效性的关键因素，因此在新药研发初期对药物膜通透性进行筛选是提高研发效率、降低研发成本的有效途径。体外评价方法因具有快速、简单等特点已成为药物膜通透性研究领域的热点。本文综述了近年来有关两相分配法、色谱测定法、毛细管电泳测定法、光学传感器测定法以及平行人工膜通透性测定法等体外测定方法在药物膜通透性评价中的应用进展。
- 新药筛选 /
- 膜通透性 /
- 体外评价方法 /
- 进展
Abstract: Membrane permeability is one of the key properties which affect drug safety and efficacy,so its evaluation is very important for enhancing drug development efficiency and reducing drug reseach spendings. Recently,in-vitro evaluation methods have become the focus in the field of drug membrane permeability researches. In this paper,the developments of in-vitro evaluation methods are summarized,including two-phase partitioning method,chromatography method,capillary electrophoresis method,optical biosensor assay and parallel artificial membrane assay.
- drug screening /
- membrane permeability /
- in-vitro evaluation methods /
- progress