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甲壳素/壳聚糖及其衍生物与血液的相互作用

Interactions of chitin,chitosan and their derivatives with blood constitutes

  • 摘要: 甲壳素/壳聚糖是来源丰富的天然有机物,具有多种生物活性且应用广泛。本文重点综述了甲壳素、壳聚糖及其衍生物的止血活性及作用机制的国内外研究进展,并列举了一些已市售或正在研制中的甲壳素/壳聚糖基止血敷料。此外,甲壳素/壳聚糖的特殊衍生物(如硫酸化衍生物)具有截然相反的抗凝血活性,因此亦对其抗凝血衍生物的研究近况进行了介绍。

     

    Abstract: Chitin and chitosan are natural organic matters with rich resources and wide applications due to their various bioactivities.In this paper,research progresses on the hemostasis activities and action mechanisms of chitin,chitosan,and their derivatives at home and abroad are summarized.Some hemostasis dressings based on chitin or chitosan are introduced.In addition,the derivatives such as sulfated derivatives showed the anticoagulant activity which contrary to chitin and chitosan,so their recent research developments are also presented..

     

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