Abstract:
Dimethylaminoethyl ginkgolide B mesylate(XQ-1H)therapeutic time window in rat focal cerebral ischemia was investigated using rat model of middle cerebral artery occlusion(MCAO,induced by intraluminal suture method).Following MCAO,different doses of XQ-1H were administered(ig)at 1,2 and 3 h,respectively. Regional cerebral blood flow,neurological score,infarction rate,water content and pathological change of rats at each interval were determined 24 h after MCAO.It was observed that the regional cerebral blood flow was increased and neurological score,cerebral infarction rate and water content were reduced significantly at 1 h,2 h(XQ-1H administered after MCAO).The results showed that the neuroprotective effect of XQ-1H on the therapeutic window in focal cerebral ischemia injury of rats was extended to 2 h.