甲磺酸胺银杏内酯B对局灶性脑缺血的治疗时间窗研究
Therapeutic time window of dimethylaminoethyl ginkgolide B mesylate in focal cerebral ischemia of rats
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摘要: 采用线栓法制作大鼠大脑中动脉闭塞（MCAO）所致脑缺血模型，研究甲磺酸胺银杏内酯B（XQ-1H）灌胃给药（ig）对局灶性脑缺血的治疗时间窗。将3批动物造模后分别于缺血后1，2，3 h给药，24 h后分别进行大鼠局部脑血流、神经行为学评分、脑梗死率、脑含水量测定以及组织形态学观察。结果显示：在脑缺血后1 h、2 h进行XQ-1H治疗给药能使局灶性脑缺血大鼠局部脑血流量增加、神经行为明显改善，脑梗死率及脑含水量显著下降，XQ-1H 于脑缺血后1 h、2 h给药对局灶性脑缺血具有显著的治疗作用。表明其灌胃给药对局灶性脑缺血的治疗时间窗为脑缺血后2 h。Abstract: Dimethylaminoethyl ginkgolide B mesylate（XQ-1H）therapeutic time window in rat focal cerebral ischemia was investigated using rat model of middle cerebral artery occlusion（MCAO,induced by intraluminal suture method).Following MCAO,different doses of XQ-1H were administered（ig）at 1,2 and 3 h,respectively. Regional cerebral blood flow,neurological score,infarction rate,water content and pathological change of rats at each interval were determined 24 h after MCAO.It was observed that the regional cerebral blood flow was increased and neurological score,cerebral infarction rate and water content were reduced significantly at 1 h,2 h（XQ-1H administered after MCAO）.The results showed that the neuroprotective effect of XQ-1H on the therapeutic window in focal cerebral ischemia injury of rats was extended to 2 h.
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