新疆一枝蒿化学成分的研究
Chemical constituents from Artemisia rupestris L.
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摘要: 采用硅胶、Sephadex LH-20、C18等柱色谱方法对新疆一枝蒿Artemisia rupestris L.干燥地上部位的醇提物进行分离纯化，得到16个化合物（ 1~16 ）。通过1H NMR、13C NMR等波谱技术,16个化合物的结构分别鉴定为：一枝蒿酮酸( 1 )，12-hydroxy-4,11(13)-guaiadien-3-one( 2 )，木犀草素( 3 )，5,7-二羟基-3′,4′-二甲氧基黄酮( 4 )，木犀草素7-O-β-D-葡萄糖苷( 5 )，木犀草素7-O-α-L-木糖-(1→6) -β-D-葡萄糖\( 6 )，蒙花苷( 7 )，槲皮素( 8 )，石吊兰素( 9 )，栀子素丁( 10 )，茵芋苷( 11 )，豆甾醇-3-O-β-D-葡萄糖苷( 12 )，1,2-O-异丙叉基-α-D-呋喃葡萄糖苷( 13 )，天师酸( 14 )，β-谷甾醇( 15 )，胡萝卜苷( 16 )。其中化合物 2 ， 4 ， 6 ， 9 ， 11~14 均为首次从该植物中分离得到。Abstract: From the ethanol extract of the aerial parts of Artemisia rupestris,sixteen compounds were isolated by repeated column chromatography with silica gel,Sephadex LH-20 and C18. Their structures were identified by spectroscopic techniques(1H NMR,13C NMR and so on) as:rupestonic acid( 1 ),12-hydroxy-4,11(13)-guaiadien- 3-one( 2 ),luteolin( 3 ),5,7-dihydroxy-3′,4′-dimethoxyflavone( 4 ),luteolin 7-O-β-D- glucoside( 5 ),luteolin 7-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside\( 6 ),linarin( 7 ),quercetin( 8 ),nevadensin( 9 ),gardenin D( 10 ),skimmin( 11 ),stigmasterol -3-O-β-D-glucopyranoside( 12 ),1,2-isopropylidene-α-D-glucopyranose( 13 ),tianshic acid( 14 ),β-sitosterol( 15 ) and daucosterol( 16 ). Among them,compounds 2,4,6,9,11-14 were isolated from this plant for the first time.
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