抗结核新靶点及相关药物的研究进展

基金项目: 国家自然科学基金资助项目（No.30973638);江苏省产学研联合创新资金资助项目（No.BY2011158)

Advances in new anti-tuberculosis targets and related drugs

摘要: 肺结核是一种由结核分枝杆菌（Mycobacterium tuberculosis）感染引起的，严重威胁人类健康的传染病。近年来，多药耐药和广泛耐药型结核杆菌的出现给该疾病的控制带来了巨大挑战，在新趋势下,迫切需要作用于新靶点的抗结核药物诞生。本文从结核杆菌细胞生长涉及的必需生物过程、结核杆菌致病和耐药机制3个角度出发,系统综述了抗结核领域新靶点及相关药物的研究进展。
- 结核分枝杆菌 /
- 抗结核 /
- 靶点 /
- 耐药 /
- 研究进展
Abstract: Tuberculosis (TB) is a major global health threat which is caused by Mycobacterium tuberculosis.The emergence of multidrug resistant (MDR) and extremely drug-resistant (XDR) TB poses a vital challenge to the control of this disease,and thus there is an urgent need for new drugs with novel targets.This review describes advances in new targets of anti-tuberculosis which are involved in the essential growth processes,mechanisms of pathogenic resistance of Mycobacterium tuberculosis.The development of related drugs for those targets is also summerized.
- Mycobacterium tuberculosis /
- anti-tuberculosis /
- target /
- drug resistance /
- advances