刺芒柄花素氮芥衍生物的合成及抗肿瘤活性

Synthesis and antitumor activity of nitrogen mustard derivatives of formononetin

摘要: 设计合成了一系列刺芒柄花素氮芥衍生物，采用MTT法评价目标化合物对HCT-116(人体结肠癌细胞系)，HeLa(人体宫颈癌细胞系)，DU-145(人体前列腺癌细胞系)，SGC-7901(人体胃癌细胞系)和SH-SY5Y(人体神经母细胞癌细胞系)的抗肿瘤活性。其体外抗肿瘤活性实验表明，许多衍生物具有明显的抗肿瘤活性，而且大部分衍生物的抗肿瘤活性高于刺芒柄花素。

Abstract: A series of formononetin nitrogen mustard derivatives were designed and synthesized.Their in vitro cytotoxicity against SH-SY5Y(human neuroblastoma cell line),HCT-116(human colon cancer cell line),DU-145 (human prostate carcinoma cell line),HeLa(human cervical carcinoma cell line) and SGC-7901(human gastric cancer cell line) was evaluated by standard MTT assay.It was found that many of the derivatives displayed significant antitumor activity,and most of the compounds showed more potent antitumor activity than that of formononetin.