Abstract: This article investigate the effect of the Jiangya Yishen（JYYS） granule on regulative system of extracellular matrix（ECM）decomposition of spontaneously hypertensive rats（SHR）,we determined the expression of include transforming growth factor β₁（TGF-β₁）,collagen type IV（COLIV）,matrix metalloproteinase-9（MMP-9）,tissue inhibitor of metalloproteinase-1（TIMP-1）by utilizing real time fluorescent PCR technique (RT-PCR) and laser confocal fluorescence microscopy.The results showed that JYYS could enhance the level of renal MMP-9 mRNA and its protein level,meanwhile down regulate the transcription of TIMP-1,TGF-β₁,COLIV and decreasing their protein level after long term treatment.Therefore,JYYS corrected the imbalance of MMP-9/TIMP-1,then enhanced the degradation of ECM and decreased the accumulation of ECM to protect kidney in SHR.