Preparation of myricetin-caffeine cocrystal and its single crystal analysis

XU Jiaojiao; WEI Yuanfeng; QIAN Shuai; ZHANG Jianjun

doi:10.11665/j.issn.1000-5048.20160313

Journal of China Pharmaceutical University > 2016 > 47(3): 324-328. > DOI: 10.11665/j.issn.1000-5048.20160313

XU Jiaojiao, WEI Yuanfeng, QIAN Shuai, ZHANG Jianjun. Preparation of myricetin-caffeine cocrystal and its single crystal analysis[J]. Journal of China Pharmaceutical University, 2016, 47(3): 324-328. DOI: 10.11665/j.issn.1000-5048.20160313

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Preparation of myricetin-caffeine cocrystal and its single crystal analysis

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Myricetin(MYR)was cocrystallized with caffeine(CAF)by suspension and the single crystal of MYR-CAF cocrystal was cultured by slow solvent evaporation. Cocrystals obtained by two different methods were the same in crystal form after characterization with X-ray diffraction. Structural analysis of single crystal of MYR-CAF showed that its crystal system and the space group were monoclinic and P2₁/n, respectively. In MYR-CAF cocrystal, 4′-OH in ring B and 7-OH in ring A of MYR interacted with CAF at(8)C=N and(2)C=O through hydrogen bonds. In comparison to the original MYR crystal, the intrinsic dissolution rate of MYR was significantly enhanced for about 17-fold after cocrystallization with CAF.
- myricetin,
- caffeine,
- cocrystal,
- single crystal,
- intrinsic dissolution rate

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