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XU Jiaojiao, WEI Yuanfeng, QIAN Shuai, ZHANG Jianjun. Preparation of myricetin-caffeine cocrystal and its single crystal analysis[J]. Journal of China Pharmaceutical University, 2016, 47(3): 324-328. DOI: 10.11665/j.issn.1000-5048.20160313
Citation: XU Jiaojiao, WEI Yuanfeng, QIAN Shuai, ZHANG Jianjun. Preparation of myricetin-caffeine cocrystal and its single crystal analysis[J]. Journal of China Pharmaceutical University, 2016, 47(3): 324-328. DOI: 10.11665/j.issn.1000-5048.20160313
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Preparation of myricetin-caffeine cocrystal and its single crystal analysis

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  • Myricetin(MYR)was cocrystallized with caffeine(CAF)by suspension and the single crystal of MYR-CAF cocrystal was cultured by slow solvent evaporation. Cocrystals obtained by two different methods were the same in crystal form after characterization with X-ray diffraction. Structural analysis of single crystal of MYR-CAF showed that its crystal system and the space group were monoclinic and P21/n, respectively. In MYR-CAF cocrystal, 4′-OH in ring B and 7-OH in ring A of MYR interacted with CAF at(8)C=N and(2)C=O through hydrogen bonds. In comparison to the original MYR crystal, the intrinsic dissolution rate of MYR was significantly enhanced for about 17-fold after cocrystallization with CAF.
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  • [1]
    Liu J,Zheng XQ,Cheng LF,et al.Effect of polymers on the formation thermodynamics of adefovir dipifoxil-saccharin cocrystal[J].J China Pharm Univ(中国药科大学学报)2015,46(2):194-200.
    [2]
    Yao Y,Lin G,Xie Y,et al.Preformulation studies of myricetin:a natural antioxidant flavonoid[J].Pharmazie,2014,69(1):19-26.
    [3]
    Hong C,Xie Y,Yao Y,et al.A novel strategy for pharmaceutical cocrystal generation without knowledge of stoichiometric ratio:myricetin cocrystals and a ternary phase diagram[J].Pharm Res,2015,32(1):47-60.
    [4]
    Vissiennon C,Nieber K,Kelber O,et al.Route of administration determines the anxiolytic activity of the flavonols kaempferol,quercetin and myricetin—are they prodrugs[J]?J Nutr Biochem,2012,23(7):733-740.
    [5]
    Schultheiss N,Newman A.Pharmaceutical cocrystals and their physicochemical properties[J].Cryst Growth Des,2009,9(6):2950-2967.
    [6]
    Wood J,Syarto J,Letterman H.Improved holder for intrinsic dissolution rate studies[J].J Pharm Sci,1965,54(7):1068.
    [7]
    Franklin SJ,Myrdal PB.Solid-state and solution characterization of myricetin[J].AAPS PharmSciTech,2015,16(6):1400-1408.
    [8]
    Dong JX,Qiang L,Tan ZC,et al.The standard molar enthalpy of formation;molar heat capacities;and thermal stability of anhydrous caffeine[J].J Chem Thermodyn,2007,39(1):108-114.
    [9]
    Stout GH,Jensen LH.X-ray Structure Determination:A Practical Guide[M].New York:Macmillan,1968.
    [10]
    Huang KS,Britton D,Etter TLMC,et al.A novel class of phenol-pyridine co-crystals for secondharmonic generation[J].J Mater Chem,1997,7(5):713-720.
    [11]
    Novak A.Hydrogen bonding in solids correlation of spectroscopic and crystallographic data[M].//Structure and Bonding.Berlin:Springer-Verlag,1974:177-216.
    [12]
    Zakeri-Milani P,Barzegar-Jalali M,Azimi M,et al.Biopharmaceutical classification of drugs using intrinsic dissolution rate(IDR)and rat intestinal permeability[J].Eur J Pharm Biopharm,2009,73(1):102-106.
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