Citation: | MEI Huifang, SUN Lixin, JIANG Zhenzhou, ZHANG Luyong. Sphingosine 1-phosphate signaling pathway:a novel target for regulation of epithelial and endothelial barrier function[J]. Journal of China Pharmaceutical University, 2016, 47(6): 654-660. DOI: 10.11665/j.issn.1000-5048.20160604 |
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Lee JF,Gordon S,Estrada R,et al.Balance of S1P1 and S1P2 signaling regulates peripheral micro慶????獬祡浲洠数瑥牲業捥?晢潩捬慩汴?愠摩桮攠獲楡潴渠?摲楥獭慡獳獴敥浲戠汭祵?楣湬?洠潶瑡楳汣敵?捡整汵汲獥孛?嵝??楩??畭爠牊?佐灨楹湳??敬氠汈??楲潴氠??楲???とべ???扬?土ど??戲????????????扢爾??嬩??崳″?婈栴愲漮?塢??倾敛渲朲?堠?卌畩渠?匬???楮?敂琬?慥汮??楃??剩漾汥整?潡晬?欯楩渾愮獄敩?楦湥摲敥灮整湩摡敬渠瑡?慴湩摶?摴敩灯敮渠摯敦渠瑲?晣略湰捴瑯楲潳渠獡?潤映?????楬渠?敡湴摨潷瑡桹敳氠極慰汯?挠敳汴汩?獵畬牡癴楩癯慮氠?慹渠摤?扦慦牥牲楥敮牴?晤畯湳捥瑳椠潯湦?摳異牨楩湮杧?敳浩扮牥礭漱渭楰捨?摳数癨敡汴潥瀠浩敮渠瑥孮?嵯??楥????攠汣汥??楳潛汊??椼???へ????批??????扩??????????????戯牢??嬱??崹‵?匱栰椷欮愼瑢慲?夾??椳牝甠欠潁癬?????楉牂甮歒潯癬慥?????楩?敲瑯?慵汢??楥???湴癯潳汫癥敬浥整湯瑮?潩普?獲楥瑧敵?獡灴敩捯楮映楯捦?????灴桨潥獬灩桡潬爠祢污慲瑲楩潥湲?楦湵?獣灴桩楯湮杛潊獝椮渼敩???灯档潨獥灭桩慳瑴敲?愨湍摯?瑣栩爼漯浩戾椬渲?椱渴搬甼换放搷?昼漯换愾氨?愩携根收猴椭漹渷‵爮攼浢潲搯放汛椲渴杝?爠潇污敲?潩晡?半片挬?慩湵搠???呥孲?嵮??楄???匾??????椯??金こば???执?????戠?????????ぴ?㈠?????扴牥??孥??嵯??坥慬湩条??????栠楢慡湲杲??呲??卮楴浥浧潲湩獴??呢???楤?攭瑤?慰汥??楥????呹奴??に?楬湥摴畡捬攠摲?桡畲浲慡湮?灥畭汥浮潴湛慊牝礮?敩渾摊漠瑃桬敩汮椠慉汮?扥慳牴爼椯敩爾?攲渰栰愱測挼敢派攱渰琸?椯獢 ̄洨攵搩椺愶琸改搮?扢祲?挾??戵汝嬠?嵗??楧??甬牂?剥敨獥灲椠牒????楷???ぅ????扥?????戯????????????扥牣??孮??嵡??偳慴牵敤歹栠????慰湡捴敩牯?剴??呰桯楲捡歬攠瑣瑹??剳??捬略瑴敯?氠畲湥条?楲湡橮畧牥祭孥?嵴??楴??汴椠湤??敥摲??楮???ふ????扬?????扭??????????????扲牴??孳??嵮??卥穮捤穯整灨慥湬楩慡歬?坰卥?婭桥慡湢杩?奩婴??慊杝攮爼瑩社?卣??楒?数琼?慩氾??椰??匬瀼桢椾渵朼漯獢椾渺攱???瀷栮潤獯灩栺愱琰攮?爰攳猸振畳敲獥?挱愱渰椹渷攮??偲匯?楛渲搶畝挠攠摃?慭捰甠瑓敍?汃畨湩条?楧渠橅畔爬祓?慮渠摃?愬氼瑩放牥獴?獡祬猼琯敩派椮捐?楬湭景汮慡浲浹愠瑥潮牤祯?捨祥瑬潩歡楬渠散?灬牬漠摢畡捲瑲楩潥湲?楥??楡湮?癥業癥潮??楢?嬠?嵯??楬?呆牔慙渷猲氰?剡敮獡??楧???づぴ???批??????戰??????????????戬牡??嬠??嵧??婣桵慲潯?奩呤???潔牙猷栲欰潛癊慝??????敥牭搠祐獨桹敳瘠?????楳?支瑩 ̄愬氲??椵???倾爱漹琱攼振瑢椾漺渱?漭昲??偤卯?椺渱搰甮挱攰搱?洯番爮楣湨敥?慰捨畹瑳敬?汰甮渲朰?椵渮樸甮爰礰?戮礼?獲瀯栾楛渲朷潝猠椠湂敥???灴档潨猠灐栬慄瑵敤?汫礠慓獍攮?獯畬灥瀠牯敦猠獆楁潋渠孩?崠??楐??浥???剡整獥灤??敮汤汯??潥汬??楬???ひ????扩?????扊??监???????????戠牒??嬼??崾?′匰由渲?堼?匾椸渳朼氯敢琾漨渱?债???攳琰献椼潢畲????椸?攠琠?慡汫??楨??卡瀠桓椮湐杨潯獳楰湨敯???灡桴潩獯灮栠慯瑦攠?特敯捳敩灮琠潲牥???楡獴?慲?渠潬癩敧汨?戠楣潨浡慩牮欠敢特?業湹?慳捩畮琠敬?汧畨湴朠?楨湡橩畮爠祫孩?嵡??椬??浤???剳散獬灥椠牣??整汲污??潩汯??楊潝氮??椾???っㄠ???扩?????戹??????监???????戲爰??嬲??崮??卲甯渾?堲???愠?卵??坫愠摓敍??卡??楢?敯瑮?慊汒??楨???畧渠捅瑔椬漼湩愾汥?瀠牡潬洼漯瑩放爮?癵慬牭楯慮湡瑲獹?楥湮?獯灴桨楥湬杩潡獬椠湣敥???灢桡潲獲灩桥慲琠敥?牨敡据散灥瑭潥牮???慹猠獳潰捨楩慮瑧敯?睩楮瑥栠?猭異獨捯敳灰瑨楡扴楥氠楲瑯祬?瑳漠?獯敲瀠獣楯獲?慡獣獴潩据椠慡瑮敤搠?慹捯畳瑩敮?牬敩獧灨楴爠慣瑨潡物祮?摫楩獮瑡牳敥獛獊?献礼湩搾牊漠浂敩孯?崠??楥??洯???倲栰礰猴椬漼汢??男渹朼????椲??呼?????戭??????戼????????????????戬牓??孧?づ嵴??传歐慁稬慂歲楯????牅攬椼獩放汥???剬椼振桩愾爮摐獨潯湳?卨???楲?敳瑩?慥氠??楯??卩灮栠楤湹杮潡獭楩湣敳???瀠档潥獬灬栠慭瑥敭?楲湡桮楥戠楲瑡獦?楳猠捯桦攠浳楰慨?牮敧灯敳物普略猭椱漭湰?楯湳橰畨牡祴?昭潳汴汩潭睵楬湡杴?敤砠灨敵牭楡浮攠湥瑮慤汯?汨略湬杩?瑭爺慲湯獬灥氠慩湮琠慢瑡楲潲湩孥?崠??楨??浣???呮牴慛湊獝瀮氼慩渾瑃??楬???での???戯????戰??????????????戲爩??嬹??崭???攰攮?卢奲? 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