Progress of research on disease-modifying osteoarthritis drugs

SU Boya; XU Yuansheng; WANG Hua; TANG Yuqing; ZHANG Shiqun; SONG Yan

doi:10.11665/j.issn.1000-5048.20210215

Journal of China Pharmaceutical University > 2021 > 52(2): 253-260. > DOI: 10.11665/j.issn.1000-5048.20210215

SU Boya, XU Yuansheng, WANG Hua, TANG Yuqing, ZHANG Shiqun, SONG Yan. Progress of research on disease-modifying osteoarthritis drugs[J]. Journal of China Pharmaceutical University, 2021, 52(2): 253-260. DOI: 10.11665/j.issn.1000-5048.20210215

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Progress of research on disease-modifying osteoarthritis drugs

Guangzhou Link Health Pharma Co., Ltd., Guangzhou 510663, China

Funds: This study was supported by the 2017 Entrepreneurial Leading Talents Project of Guangzhou Development District(No.2020-L042)

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Received Date: October 21, 2020
Revised Date: March 04, 2021

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Abstract

Abstract

Osteoarthritis (OA) is a common chronic joint disease,whose main pathological changes are the degeneration of articular cartilage and secondary bone hyperplasia.The limitation of current treatment methods including pain relief and joint replacement surgery is that they cannot fundamentally improve the damage of articular cartilage.The emergence of disease-modifying osteoarthritis drugs (DMOAD) may break the above limitations.They fundamentally inhibit the structural degeneration of articular cartilage by participating in the regulation of cartilage metabolic balance, regulation of subchondral bone remodeling,and control of local inflammation.Thereby,OA patients will get symptom improvement including pain relief and joint function restoration,delay the artificial joint replacement surgery, and improve the quality of life. There are still no DMOAD drugs widely available on the market worldwide.This paper reviews the background of R&D,the classification of mechanisms of action and research progress of representative drugs under different inechanisms so as to provide reference for future research.
- osteoarthritis,
- disease-modifying of osteoarthritis drug,
- cartilage repair,
- subchondral bone remodeling,
- inflammation

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References (50)

References

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