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DAI Jiangdong, LI Huipeng, SUN Minjie. Effects of polyethylene glycol length on oral absorption of coumarin 6-loaded nanostructured lipid carrier[J]. Journal of China Pharmaceutical University, 2021, 52(3): 293-300. DOI: 10.11665/j.issn.1000-5048.20210305
Citation: DAI Jiangdong, LI Huipeng, SUN Minjie. Effects of polyethylene glycol length on oral absorption of coumarin 6-loaded nanostructured lipid carrier[J]. Journal of China Pharmaceutical University, 2021, 52(3): 293-300. DOI: 10.11665/j.issn.1000-5048.20210305
shu

Effects of polyethylene glycol length on oral absorption of coumarin 6-loaded nanostructured lipid carrier

  • 1.

    Jiangsu Jianhu People's Hospital,Yancheng 224700

  • 2.

    Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China

Funds: This study was supported by the National Natural Science Foundation of China (No.81872817) and the "Double First-Class" University Project of China Pharmaceutical University (No. CPU2018GY07)
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  • Received Date: July 14, 2020
  • Revised Date: May 25, 2021
    Graphical Abstract
    • Abstract
  • Polyethylene glycol (PEG) of different lengths were prepared to investigate their effects on oral absorption of nanostructured lipid carrier (NLCs).Three kinds of PEG-modified NLCs with different chain lengths, including polyethylene glycol (100) monostearate (S100), polyethylene glycol (55) monostearate (S55), polyethylene glycol (40) monostearate (S40), were prepared by film dispersion method.Coumarin 6 was chosen as a fluorescent probe to characterize the physicochemical properties of NLCs with different lengths.Meanwhile, the stability of NLCs in simulate buffer, the release behavior, cytotoxicity of NLCs, the uptake kinetics and cellular uptake mechanisms were evaluated. This work demonstrated that the thickness of the hydrated layer increased with the increase of PEG length. Of note, S100-modified NLCs (pNLC-EG100) exhibited higher cellular uptake efficiency compared with other formulations. Thus, S100 was optimized as the best molecular weight for PEG-modified NLCs on oral drug delivery system.
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    • References (14)
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