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FAN Wanjun, ZHANG Jiayin, WANG Chen, ZHANG Ziqiang, HE Shuwang, YAO Jing. Therapeutic effect of celecoxib-loaded microspheres on rheumatoid arthritis in rats after intra-articular injection[J]. Journal of China Pharmaceutical University, 2021, 52(5): 573-578. DOI: 10.11665/j.issn.1000-5048.20210509
Citation: FAN Wanjun, ZHANG Jiayin, WANG Chen, ZHANG Ziqiang, HE Shuwang, YAO Jing. Therapeutic effect of celecoxib-loaded microspheres on rheumatoid arthritis in rats after intra-articular injection[J]. Journal of China Pharmaceutical University, 2021, 52(5): 573-578. DOI: 10.11665/j.issn.1000-5048.20210509
shu

Therapeutic effect of celecoxib-loaded microspheres on rheumatoid arthritis in rats after intra-articular injection

  • 1.

    School of Pharmacy, China Pharmaceutical University, Nanjing 210009

  • 2.

    Nanjing Zeheng Pharmaceutical Technology Development Co.,Ltd, Nanjing 210046

  • 3.

    Shandong Dyne Marine Biopharmaceutical Co.,Ltd, Rongcheng 246300, China

Funds: This study was supported by the National Science and Technology Major Project (No. 2018ZX09721003-007-005)
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  • Received Date: March 17, 2021
  • Revised Date: September 13, 2021
    Graphical Abstract
    • Abstract
  • This study sought to assess the therapeutic effect of celecoxib (CEL)-loaded polylactic acid-glycolic acid copolymer (PLGA) microspheres on rheumatoid arthritis in rats after intra-articular injection.The celecoxib-loaded microspheres (CEL-MS) were prepared by the O/W solvent volatilization method with PLGA as carrier.In order to investigate the therapeutic effect of CEL-MS on rheumatoid arthritis in rats after intra-articular injection, a rat model of adjuvant arthritis (AA) was constructed by complete Freund''s adjuvant, and the evaluation indicators of the therapeutic effect were rat paw swelling, arthritis index,spleen index and joint synovial histopathological examination. The results showed that the microspheres had a smooth spherical morphology with a particle size of (2.1 ± 0.3) μm and a drug loading efficiency of (20.8 ± 0.6)%.The results of the in vivo efficacy test showed that intra-articular injection of CEL-MS compared to the CEL suspension oral and the celecoxib suspension intra-articular injection in adjuvant arthritis rat model can significantly reduce joint swelling and arthritis index, thus effectively inhibiting synovial inflammation.The above results indicate that intra-articular injection of CEL-MS has a good therapeutic effect on rheumatoid arthritis in rats.
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    • References (18)
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