Pharmacological Studies on Polysaccharides of Polystictus Versicolor

Inhibition of polysaccharides on sarcoma 180 and the immune response of polysaccharides were studied.Polysaccharides of polystictus versicolor used in this experiment were obtained from its mycelium ( PV -1 ) and culture medium ( PV -4 ) . when the polvsaccharides were administered intraperitoneally in daily dose of 10-100mg/kg to sarcoma 180 bearing mice for 10 to 35 days, it was found to have a faint inhibition. PV - 4 couLd not potentiate the inhibition of cyclophosphamide on sarcoma 180, on the contrary it decreased the effect, when daily dose 200mg/kg of polysaccharides was continued for 3 days, they have caused infant mice to lose the thymus weight but to gain the spleen weight. PV - 1 prolong the time of sleeping induced by pentobarbtal.In the normal mice, as well as in these mice suffering from impaired liver caused by carbontetrachloride, when PV - 1 was administered subcutaneously in dose of 100mg/kg for 7 days, it has been found to enhance the phagocytosis of microphage,Studies of acute toxicity have shown that the LD50 of PV - 1 is 2750 mg/kg, PV - 4is 2883 mg/kg for intraperitoneal administration in mice,