Studies on Synthesis of Leflunomide

Studies on Synthesis of Leflunomide[J]. Journal of China Pharmaceutical University, 2000, (5): 10-11.

Citation:

Studies on Synthesis of Leflunomide[J]. Journal of China Pharmaceutical University, 2000, (5): 10-11.

Citation:

Studies on Synthesis of Leflunomide[J]. Journal of China Pharmaceutical University, 2000, (5): 10-11.

Abstract

Leflunomide was synthesized via five steps with ethyl acetoacetate as starting material. The total yield was 46.3%. The condition of reaction was mild and suitable for industry-scale manufacture.

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