Separation of the Main Impurity P-demethylgatifloxacin from Gatifloxacin and its Synthesis and Identification[J]. Journal of China Pharmaceutical University, 2003, (3): 78-79.
Citation:
Separation of the Main Impurity P-demethylgatifloxacin from Gatifloxacin and its Synthesis and Identification[J]. Journal of China Pharmaceutical University, 2003, (3): 78-79.
Separation of the Main Impurity P-demethylgatifloxacin from Gatifloxacin and its Synthesis and Identification[J]. Journal of China Pharmaceutical University, 2003, (3): 78-79.
Citation:
Separation of the Main Impurity P-demethylgatifloxacin from Gatifloxacin and its Synthesis and Identification[J]. Journal of China Pharmaceutical University, 2003, (3): 78-79.
Separation of the Main Impurity P-demethylgatifloxacin from Gatifloxacin and its Synthesis and Identification
AIM:To identify the main impurity of gatifloxacin.METHOD:P-demethylgatifloxacin was synthesized in four steps from ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino) acrylate through cyclization,chelation,N-piperazination and hydrolysis,and i
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