Synthesis and anti-tumor activity of novel betulinic acid derivatives

ZHU Zi-fei; TANG Jia; WANG Ting-ting; CHEN Li

ZHU Zi-fei, TANG Jia, WANG Ting-ting, CHEN Li. Synthesis and anti-tumor activity of novel betulinic acid derivatives[J]. Journal of China Pharmaceutical University, 2012, 43(5): 395-400.

Citation:

ZHU Zi-fei, TANG Jia, WANG Ting-ting, CHEN Li. Synthesis and anti-tumor activity of novel betulinic acid derivatives[J]. Journal of China Pharmaceutical University, 2012, 43(5): 395-400.

Citation:

ZHU Zi-fei, TANG Jia, WANG Ting-ting, CHEN Li. Synthesis and anti-tumor activity of novel betulinic acid derivatives[J]. Journal of China Pharmaceutical University, 2012, 43(5): 395-400.

Synthesis and anti-tumor activity of novel betulinic acid derivatives

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A series of novel derivatives of betulinic acid(BA)-nitrate and BA-furoxan hybrids were synthesized by coupling NO donors with BA via various linkers.The compounds were structurally characterized by IR,MS and ¹H NMR,and their anti-tumor activity was determined in human hepatocellular carcinoma HepG2 cells and murine melanoma B16 cells by MTT assay.The preliminary results indicated that BA-furoxan conjugates exhibited stronger cytotoxic activity than BA in HepG2 and B16 cells and were worthy of further investigation.

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Synthesis and anti-tumor activity of novel betulinic acid derivatives

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