Synthesis and anti-angiogenesis evaluation of mutual prodrugs of lenalidomide and glucosamines

To improve the targeting effect of lenalidomide on cancer cells,eight coupling compounds( 4a-4h ) of lenalidomide and aminosaccharides were designed and synthesizedTheir structures were characterized by IR,¹H NMR,MS and elemental analysisPreliminary biological evaluation results showed that compounds 4a-4c could inhibit HUVEC cell proliferation in vitro.