萘丁美酮的合成工艺改进

萘丁美酮的合成工艺改进[J]. 中国药科大学学报, 2004, (1): 92-93.

引用本文:

萘丁美酮的合成工艺改进[J]. 中国药科大学学报, 2004, (1): 92-93.

Improved Synthetic Process of Nabumetone[J]. Journal of China Pharmaceutical University, 2004, (1): 92-93.

Citation:

Improved Synthetic Process of Nabumetone[J]. Journal of China Pharmaceutical University, 2004, (1): 92-93.

Improved Synthetic Process of Nabumetone

摘要: 萘丁美酮(nabumetone)是英国Beecham公司开发的一种长效非甾体抗炎镇痛药1,具有很强抗炎活性,口服易吸收,而且胃肠道刺激小,不良反应少,耐受性好2.

Abstract: AIM:To enhance the yield of Nabumeton e,and to improve the previous synthetic method METHOD: Nabumetone is prepared with cheap reagen ts via only three steps RESULT: The cost is reduced and th e yield is increased by 2184% in the suggested method Therefor

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