酮洛芬微乳凝胶的制备及透皮机制

熊小英; 李娟

酮洛芬微乳凝胶的制备及透皮机制

熊小英,
李娟

Studies on the microemulsion-based hydrogel formulation of ketoprofen and the transdermal mechanism

摘要

摘要: 制备酮洛芬微乳凝胶，研究其体外透皮特性及可能的机制。以伪三元相图为基础、累积渗透量和皮肤滞留量为指标，用改进的 Franz扩散池考察微乳处方中各成分的用量及凝胶基质的存在对离体鼠皮透皮特性的影响。运用DSC、HE染色法和荧光标记技术进行透皮机制研究。结果表明，酮洛芬微乳与微乳凝胶体外透皮8 h的皮肤滞留量分别为(705.13±33.18)和（502.75±28.54）μg/cm²，是溶液对照组的4.66和3.22倍。微乳与微乳凝胶处理后，皮肤角质层类脂结构被破坏，细胞间隙增加，香豆素标记制剂主要分布于皮肤表层和毛囊等部位。

Abstract: This study was to prepare ketoprofen loaded microemulsion-based hydrogel(MBH) and investigate its transdermal mechanism.The pseudo-ternary phase diagrams for O/W microemulsion regions were constructed.Various microemulsion formulations were prepared and the abilities of various microemulsions to deliver ketoprofen through the skin were evaluated in vitro using Franz diffusion cells fitted with mouse skins.The data showed that the drug in microemulsions/MBH resorted in skin (705.13±33.18) and (502.75±28.54) μg/cm²,which were 4.66 and 3.22 times the control group.The DSC and HE studies showed that microemulsion/MBH affected the normal lipid packing of stratum corneum to enhance the drug permeation.Coumarin-6 labeled preparation were mainly distributed in the stratum corneum and hair follicle.

HTML全文

参考文献(0)

施引文献

资源附件(0)