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WANG Jianming, CHEN Yanmei, ZHANG Hailu, ZHANG Yanfeng, CHEN Minhua. Crystal form identification of dasatinib in tablets[J]. Journal of China Pharmaceutical University, 2015, 46(5): 575-578. DOI: 10.11665/j.issn.1000-5048.20150510
Citation: WANG Jianming, CHEN Yanmei, ZHANG Hailu, ZHANG Yanfeng, CHEN Minhua. Crystal form identification of dasatinib in tablets[J]. Journal of China Pharmaceutical University, 2015, 46(5): 575-578. DOI: 10.11665/j.issn.1000-5048.20150510
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Crystal form identification of dasatinib in tablets

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  • The aim of this study was to establish the methods to identify crystal form of dasatinib in tablets. X-ray powder diffraction(XRPD)and solid-state nuclear magnetic resonance(ssNMR)were used to analyze the crystal form of dasatinib in Sprycel® tablets and Yinishu® tablets. The results showed that monohydrate and anhydrate were identified in Sprycel® and Yinishu® tablets respectively, with no detectable anhydrate in Sprycel® tablets and no detectable monohydrate in Yinishu® tablets. The results of XRPD and ssNMR were consistent, and could be both applied in the crystal form identification of dasatinib in tablets.
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