New materials and new technology of plant soft capsules

LUO Jinjie; LIN Huaqing; YANG Xiaoxia

doi:10.11665/j.issn.1000-5048.20150520

Journal of China Pharmaceutical University > 2015 > 46(5): 635-640. > DOI: 10.11665/j.issn.1000-5048.20150520

LUO Jinjie, LIN Huaqing, YANG Xiaoxia. New materials and new technology of plant soft capsules[J]. Journal of China Pharmaceutical University, 2015, 46(5): 635-640. DOI: 10.11665/j.issn.1000-5048.20150520

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New materials and new technology of plant soft capsules

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Abstract

With the popularity of the concept of being “natural” and “vegetarian”, plant soft capsules have gained widespread attention in pharmaceutical markets of many countries. Looking for new materials of plant soft capsules and developing the new technologies have become a inevitable requirement due to the traditional gelatin soft capsules could not meet the increasing daily life demand of people. The review illustrates the characteristics of the commonly used plantsoft capsule materials such as modified starch, gelatin or synthetic polymers, as well as the application of advanced technology concerning capsule shell and core material, providing a reference for the development and application of new plant soft capsules. The promising expectation of plant soft capsules are also illustrated.
- plant soft capsules,
- new materials,
- new technology,
- research,
- progress

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[1]	Zeng JC,Huang CX,Wu XC,et al.Advances in researches of non-gelatin soft capsule shell compositions[J].Mod Food Sci Technol(现代食品科技),2012,28(9):1266-1271.
[2]	Zhang L,Wanga YF,Liu HS.Developing hydroxypropyl methylcellulose /hydroxypropyl starch blends for use as capsule materials[J].Carbohydr Polym,2013,98(1):73-79.
[3]	Wang XJ,Zhang KS,Ren YX,et al.Study on the gelling properties of sodium alginate[J].Sci Technol Food Ind(食品工业科技),2008,29(2):259-262.
[4]	FMC Corporation.High strength seamless alginate capsules: US,20100874618[P].2011-03-10.
[5]	Guo WQ,Tang HS.Alginate as raw material in the production plant hollow hard capsules[J].Sci Technol Gelatin(明胶科学与技术),2011,31(4):182.
[6]	Liu LM,Han L,Yang M.The research progress of plant hollow capsules[J].Pharm Clin Chin Mater Med(中药与临床),2014,5(5):60-63.
[7]	Sirio Pharma Co.,Ltd.A revolutionary soft capsules plant gum created by Sirio pharmaceutical[J].Sci Technol Food Ind(食品工业科技),2014,35(12):28.
[8]	Al-Tabakha MM.HPMC capsules:current status and future prospects[J].J Pharm Pharm Sci,2010,13(3):428-442.
[9]	Zhang YD,Zhao M,Shao ZQ,et al.Study on the pharmaceutical raw materials film performance of the plant capsule[J].Guangzhou Chem(广州化学),2012,37(4):12-17.
[10]	Tuleu C,Khela MK.A scintigraphic investigation of the disintegration behaviour of capsules in fasting subjects:a comparison of hypromellose capsules containing carrageenan as a gelling agent andstandard gelatin capsules[J].Eur J Pharm Sci,2007,30(3/4):251-255.
[11]	Jones BE,Basit AW,Tuleu C,et al.The disintegration behaviour of capsules in fed subjects:a comparison of hypromellose(carrageenan)capsules and standard gelatin capsules[J].Inter J Pharm,2012,424:40-43.
[12]	Brown A,Matthews WM,Margetson DN,et al.Hydroxypropyl cellulose capsule shells:CN,200980131187.6[P].2011-07-06.
[13]	Huang LP,Tu JS.Advances of the graft copolymers of pullulan as pharmaceutical carriers[J].J China Pharm Univ(中国药科大学学报),2015,46(4):488-492.
[14]	Zhang L.Pullulan soft capsule and its preparation method:CN,201410218210.8[P].2014-08-06.
[15]	Lian ZG,Tong QY.Study on formula optimization pullulan-based soft capsule shell[J].Sci Technol Food Ind(食品工业科技),2012,33(11):283-285,288.
[16]	Liang XJ.A plant hollow capsules and soft capsules composition and its preparation method:CN,101708174[P].2010-05-19.
[17]	Liu KP,Jiao DD,Zhang FY.Stability of starch capsule shell about moisture content and atmosphere resisting ability[J].Lishizhen Med Mater Med Res(时珍国医国药),2007,18(2):439-440.
[18]	Fonkwe LG,Archibald DA,Gennadios A.The non-gelatin capsule shells formulation comprised iota and kappa carrageenan:CN,1649572[P].2005-08-03.
[19]	Modliszewski JJ,Sewall CJ.The homogeneous thermoreversible gelatin film containing κ-2 carrageenan and its soft capsules:CN,1791389[P].2006-06-21.
[20]	Guo R,Ding EY.Structure performance and applications of xanthan gum[J].China Surfactant Detergent Cosmet(日用化学工业),2006,36(1):42-45.
[21]	Zhang YY,Hong Y,Gu ZB.Rheological and gel properties of corn starch-xanthan mixed systems[J].Trans Chin Soc Agric Eng(农业工程学报),2011,27(9):357-362.
[22]	Wen CX,Liu ZD.A review of research on gellan gum[J].China Food Additives(中国食品添加剂),2014,(1):204-207.
[23]	Zhu GL,Tong QY.Properties of gellan-carboxyl methyl cellulose mixed gels[J].Food Sci(食品科学),2014,35(19):115-118.
[24]	Cai N,Tu JS.A review of research on non-gelatin soft capsule[J].Pharm Clin Res(药学与临床研究),2008,16(3):208-212.
[25]	Wang YL,Huang SE,Wei Y,et al.Rheological properties and microstructure of κ-carrageenan-konjac gum mixed gel[J].J Chin Inst Food Sci Technol(中国食品学报),2012,12(7):49-54.
[26]	Xu YH,Han H,Li RY,et al.Preparation of fructan-containing soft capsule shell:CN,201110170404.1[P].2012-01-25.
[27]	Winston JRPE,Miskiel FJ,Valli RC.Composition and process for gelatin-free soft capsules:US,5342626[P].1994-08-30.
[28]	Wang SY,Wang CH.One kind of formulation and production process of the production of soft capsule shell with plant gum:CN,101273978[P].2008-10-01.
[29]	Zheng WJ,Liu JP,Chen HD,et al.An overview on soft capsule shell compositions[J].Prog Pharm Sci(药学进展),2007,31(11):491-495.
[30]	Pan SF.A material formulation of soft capsule:CN,201410549533.5[P].2015-02-04.
[31]	Augean M,Corte K,Sanner A,et al.The use and production method of soft capsules containing polymer with vinyl ester and polyether:CN,1212832[P].2005-08-03.
[32]	Natural Products Insider.BioProgress licenses Xgel film[EB/OL].http://www.naturalproductsinsider.com/articles/2000/09/bioprogress-licenses-xgel-film.aspx.
[33]	Hang JY,Li L.Studies on the preparation conditions of formaldehyde dip method[J].J Guiyang Med Coll(贵阳医学院学报),2001,26(2):107-108.
[34]	Xiang HY.Potent mucus chelating agents-lemon eucalyptus pinene enteric soft capsules[J].Cent South Pharm(中南药学),2010,8(3):237-240.
[35]	Suheung Capsule Co.,Ltd.Enteric coated soft capsule composition containing purified fish oil and its preparation method:KR,20120070743[P].2014-01-09.
[36]	Zhu FH.Preparation of soft capsules with biological regulation:CN,1432356A[P].2003-07-30.
[37]	Brown MD,Muncaster BJ,Nowak EZ.Capsule based drug delivery system:US,6352719[P].2002-05-05.
[38]	Sunohara H,Kamaguchi R,Kagawa M,et al.Multilayered soft capsule for eliminating bad breath and process for producing the same:US,6426089[P].2002-07-30.
[39]	Jiang YX,Yang DJ.Coconut oil soft capsule and its preparation method:CN,102907678A[P].2013-02-06.
[40]	Barakat NS.Self-emulsifying system for improving drug dissolution and bioavailability: in vitro/in vivo evaluation[J].Drug Dev Res,2010,71(2):149-158.
[41]	Wu LH,Shao B,Cui C.One kind of self-emulsifying soft capsules with piperine and its preparation method:CN,103181913A[P].2013-07-03.
[42]	Xu GQ,Su F,He GW.Development of HPMC in pharmaceutical formulations[J].Guangzhou Chem Ind(广州化工),2014,42(4):5-7,28.

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