Advances in self-assembled peptide hydrogels for bone regeneration

XU Liu; XU Shan; XIANG Tangyong; SHA Zhengzhou; ZHANG Jian; CHEN Zhipeng

doi:10.11665/j.issn.1000-5048.20220314

Journal of China Pharmaceutical University > 2022 > 53(3): 356-364. > DOI: 10.11665/j.issn.1000-5048.20220314

XU Liu, XU Shan, XIANG Tangyong, SHA Zhengzhou, ZHANG Jian, CHEN Zhipeng. Advances in self-assembled peptide hydrogels for bone regeneration[J]. Journal of China Pharmaceutical University, 2022, 53(3): 356-364. DOI: 10.11665/j.issn.1000-5048.20220314

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Advances in self-assembled peptide hydrogels for bone regeneration

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

Funds: This study was supported by the National Natural Science Foundation of China (No. 82173992) and the Postgraduate Research & Practice Innovation Program of Jiangsu Province (No.KYCX_201491)

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Received Date: February 06, 2022
Revised Date: May 04, 2022

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Abstract

Abstract

The development of osteoinductive bone-filling biomaterials for bone regeneration is of great significance.Self-assembled peptide hydrogels with high biomimetic extracellular matrix structure, low immunogenicity, easy synthesis and modification, and flexible loading capacity provide a highly efficient therapeutic platform for bone tissue repair.Herein, we discuss the design principles of self-assembled peptide hydrogels, report the structural characteristics and assembly mechanisms of self-assembled peptides, and highlight recent advances in self-assembled peptide hydrogels for bone regeneration, including delivery to cells , bone morphogenetic proteins, active factors and small molecular substances.Finally, the bottleneck and development direction of self-assembled peptide hydrogels are pointed out, aiming to provide guidance for the construction of hydrogel delivery systems with high osteogenic properties.
- self-assembly,
- peptide,
- bone reparation,
- hydrogel,
- biomaterials

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