Research progress of nitroxide radical derivatives and their biological activities

ZHANG Qili; TIAN Xue; WANG Jie; ZHAO Lei; XIA Pengfei; XU Yanli; XU Fumei; JIA Yinqiang

doi:10.11665/j.issn.1000-5048.2023041902

Journal of China Pharmaceutical University > 2024 > 55(5): 673-684. > DOI: 10.11665/j.issn.1000-5048.2023041902

ZHANG Qili, TIAN Xue, WANG Jie, et al. Research progress of nitroxide radical derivatives and their biological activities[J]. J China Pharm Univ, 2024, 55(5): 673 − 684. DOI: 10.11665/j.issn.1000-5048.2023041902

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Research progress of nitroxide radical derivatives and their biological activities

ZHANG Qili^{1, 2, 3},
TIAN Xue¹,
WANG Jie¹,
ZHAO Lei^{1, 4, 5, 6, ,},
XIA Pengfei^{1, 4, 5},
XU Yanli^{1, 6},
XU Fumei¹,
JIA Yinqiang¹

1.
Gansu University of Chinese Medicine, Lanzhou 730000
2.
Gansu Pharmaceutical Industry Innovation Research Institute, Lanzhou 730000
3.
Northwest Collaborative Innovation Center for Traditional Chinese Medicine Co-constructed by Gansu Province & MOE of PRC, Lanzhou 730000
4.
Gansu Provincial Engineering Laboratory for TCM Standardization Technology and Popularization, Lanzhou 730000
5.
Key Laboratory of Chemistry and Quality for Traditional Chinese Medicine(TCM)of Colleges of Gansu Province, Lanzhou 730000
6.
Lanzhou Institute for Food and Drug Control, Lanzhou 730000, China

Funds: This work was supported by the National Natural Science Foundation of China (No. 82160457, No. 81660577); the Natural Science Foundation of Gansu Province (No. 21JR7RA564); the Double First-class Key Scientific Research Project of Gansu Provincial Department of Education (GSSYLXM-05); the Open Fund of Gansu Province Engineering Laboratory for TCM Standardization Technology and Popularization (ddyc-2022-03); and the College Teachers Innovation Fund of Gansu Province（2023B-115）

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Received Date: April 18, 2023

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Abstract

Abstract

Nitroxide radicals are a kind of stable organic free radicals. Due to the presence of N-O· and unpaired electrons in its structure, it has many characteristics, and thus can be used as a spin marker to explore the mechanism of biological reactions; with its magnetic properties, it can be used for the development of multifunctional magnetic molecular materials and used as a polymerization inhibitor and catalyst in organic reactions. More importantly, it has a variety of biological activities such as anti-oxidation and anti-tumor, and so has attracted much attention in the research and development of new drugs. For example, the spin labeling of nitroxide radicals on anticancer drug podophyllotoxin can enhance the efficacy and reduce the toxicity, and can be easily to be absorbed by the body, thus obtaining a new anti-cancer drug 4-[4″-(2″,2″,6″,6″-tetramethyl-1″-piperidinyloxy nitroxide radical) amino]-4′-demethyl epipodophyllotoxin(GP-7). It is an effective way to seek new drugs by introducing pharmacophore to modify nitroxide radicals or it can be spin-labeled on active natural products to obtain new compounds with high efficiency and low toxicity. The research progress of derivatives and its biological activitives of nitroxide radicals are summarized, aiming to provide theoretical basis for the developing and utilizing of nitroxide radicals and searching for new drugs.
- nitroxide radicals,
- structural modification,
- derivative,
- bioactivity,
- research progress

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References

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