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外排体作为新型给药系统的研究进展

王舒, 张振海, 顾冬飞, 周建平, 吕慧侠

王舒, 张振海, 顾冬飞, 周建平, 吕慧侠. 外排体作为新型给药系统的研究进展[J]. 中国药科大学学报, 2014, 45(2): 247-252. DOI: 10.11665/j.issn.1000-5048.20140221
引用本文: 王舒, 张振海, 顾冬飞, 周建平, 吕慧侠. 外排体作为新型给药系统的研究进展[J]. 中国药科大学学报, 2014, 45(2): 247-252. DOI: 10.11665/j.issn.1000-5048.20140221
WANG Shu, ZHANG Zhenhai, GU Dongfei, ZHOU Jianping, LYV Huixia. Advances of exosomes as a new drug delivery system[J]. Journal of China Pharmaceutical University, 2014, 45(2): 247-252. DOI: 10.11665/j.issn.1000-5048.20140221
Citation: WANG Shu, ZHANG Zhenhai, GU Dongfei, ZHOU Jianping, LYV Huixia. Advances of exosomes as a new drug delivery system[J]. Journal of China Pharmaceutical University, 2014, 45(2): 247-252. DOI: 10.11665/j.issn.1000-5048.20140221

外排体作为新型给药系统的研究进展

基金项目: 中央高校基本科研业务费专项资金资助项目(No.JPKQ2011016)

Advances of exosomes as a new drug delivery system

  • 摘要: 外排体是由多泡体或称为多囊体与细胞膜融合并分泌到胞外的一种膜性小囊泡,具有多种免疫功能,其表面含有大量的与其来源和功能密切相关的蛋白质和脂质成分,具有去除细胞生长过程中的废弃蛋白、信号传导、提呈抗原激活T细胞以及诱发和增强机体免疫反应等功能。近年来,有研究者利用外排体负载药物,将其发展成为一种纳米给药体系,以避免某些外源性纳米载体可能发生的不良反应以及免疫排斥反应。本文综述了对这种新型纳米载体的发现、功能以及作为给药载体的研究进展,以丰富药剂学的载药系统,并为纳米给药系统的研究提供新的思路。
    Abstract: Exosome is a kind of immune functional membrane vesicles secreted from multivesicular body fusing with cell membrane. It contains a large number of closely related functional protein and lipid components, with the functions of cell growth proteins waste removal, signal transduction, antigen presentation, cells activation, inducing and enhancing immune response. In recent years, some researchers used exosomes as nanocarriers to avoid the possible side-effects and immune rejection of usual exogenous nanocarriers. This review briefly describes its discovery, function and development as a drug carrier with reference to some recent research papers to replenish a novel drug delivery system.
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出版历程
  • 刊出日期:  2014-04-24

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