Abstract: The pharmacokinetic translation from bench to bedside has been an important component in translational research. Based on non-clinical pharmacokinetic research results, scale factor allometric model and physiology- based pharmacokinetic model were used to investigate the translational method of pharmacokinetic parameters from quantitative pharmacology perspective. The method includes the reasonable extrapolation of translation for inter-species and analysis of in vivo-in vitro differences. The pharmacokinetic translation model from bench to bedside will help to optimize clinical administration into simulation study.