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非临床药代动力学的临床转化研究进展

郝琨, 余丹, 王广基

郝琨, 余丹, 王广基. 非临床药代动力学的临床转化研究进展[J]. 中国药科大学学报, 2015, 46(1): 50-57. DOI: 10.11665/j.issn.1000-5048.20150105
引用本文: 郝琨, 余丹, 王广基. 非临床药代动力学的临床转化研究进展[J]. 中国药科大学学报, 2015, 46(1): 50-57. DOI: 10.11665/j.issn.1000-5048.20150105
HAO Kun, YU Dan, WANG Guangji. Pharmacokinetic translational research from bench to bedside[J]. Journal of China Pharmaceutical University, 2015, 46(1): 50-57. DOI: 10.11665/j.issn.1000-5048.20150105
Citation: HAO Kun, YU Dan, WANG Guangji. Pharmacokinetic translational research from bench to bedside[J]. Journal of China Pharmaceutical University, 2015, 46(1): 50-57. DOI: 10.11665/j.issn.1000-5048.20150105

非临床药代动力学的临床转化研究进展

基金项目: 国家自然科学基金资助项目(No.81302839)

Pharmacokinetic translational research from bench to bedside

  • 摘要: 非临床药代动力学的临床转化是转化医学研究的重要组成部分。以非临床药代动力学研究结果为基础,以定量药理学为视角,采用异速校正模型和生理药代动力学模型等方法,对非临床药代动力学结果向临床药代动力学结果转化的方法进行综述,内容包括药代动力学参数体内外及种属间的相互连接,全方位解析药代动力学转化的种属间和体内外差异,为药物的临床药代动力学试验和临床给药方案调整提供了理论依据和实验基础。
    Abstract: The pharmacokinetic translation from bench to bedside has been an important component in translational research. Based on non-clinical pharmacokinetic research results, scale factor allometric model and physiology- based pharmacokinetic model were used to investigate the translational method of pharmacokinetic parameters from quantitative pharmacology perspective. The method includes the reasonable extrapolation of translation for inter-species and analysis of in vivo-in vitro differences. The pharmacokinetic translation model from bench to bedside will help to optimize clinical administration into simulation study.
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  • 刊出日期:  2015-02-24

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