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双环[1.1.1]戊烷衍生物的合成研究进展

黄雨, 张寅生

黄雨, 张寅生. 双环[1.1.1]戊烷衍生物的合成研究进展[J]. 中国药科大学学报, 2022, 53(2): 137-145. DOI: 10.11665/j.issn.1000-5048.20220202
引用本文: 黄雨, 张寅生. 双环[1.1.1]戊烷衍生物的合成研究进展[J]. 中国药科大学学报, 2022, 53(2): 137-145. DOI: 10.11665/j.issn.1000-5048.20220202
HUANG Yu, ZHANG Yinsheng. Advances in the synthetic methods of bicyclo[1.1.1]pentane derivatives[J]. Journal of China Pharmaceutical University, 2022, 53(2): 137-145. DOI: 10.11665/j.issn.1000-5048.20220202
Citation: HUANG Yu, ZHANG Yinsheng. Advances in the synthetic methods of bicyclo[1.1.1]pentane derivatives[J]. Journal of China Pharmaceutical University, 2022, 53(2): 137-145. DOI: 10.11665/j.issn.1000-5048.20220202

双环[1.1.1]戊烷衍生物的合成研究进展

基金项目: 江苏省抗病毒靶向药物研究重点实验室资助项目([2019]No.1627)

Advances in the synthetic methods of bicyclo[1.1.1]pentane derivatives

Funds: This study was supported by the Program of Jiangsu Key Laboratory of Targeted Antiviral Research ([2019] No.1627)
  • 摘要: 双环[1.1.1]戊烷(BCP)是一种具有三维立体结构的桥环骨架,其作为苯环、叔丁基和炔烃的生物电子等排体,已经在药物化学领域得到广泛的应用。随着BCP应用范围的扩大,BCP及其衍生物的合成日益成为研究的热点。本文对BCP衍生物的主要合成策略和方法进行总结,旨在为新药研发人员提供参考。
    Abstract: Bicyclo [1.1.1] pentane (BCP) is a kind of bridged ring skeleton with a three-dimensional structure. As a bioisostere of benzene ring, tert-butyl and alkyne, it has been widely used in the field of medicinal chemistry.With the expansion of its application, the synthesis of BCP and its derivatives has become an increasingly attractive research hotspot for scientists.Based on this, the present article summarizes the main synthetic strategies and methods of BCP derivatives, in the hope of providing some reference for drug discovery researchers and some insight for new synthetic methods of such compounds.
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出版历程
  • 收稿日期:  2021-10-31
  • 修回日期:  2021-12-21
  • 刊出日期:  2022-04-24

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