脂肪乳在药物中毒解救中的应用研究

李植; 李蒙; 孙昊; 刘东飞

doi:10.11665/j.issn.1000-5048.20220313

脂肪乳在药物中毒解救中的应用研究

1.
中国药科大学药剂学教研室，天然药物活性组分与药效国家重点实验室，南京 210009
2.
南京医科大学第一附属医院急诊医学中心，南京 210029

基金项目: 国家自然科学基金资助项目（No.82172184，No.81973266）

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出版历程
- 收稿日期: 2021-12-13
- 修回日期: 2022-04-28
- 刊出日期: 2022-06-24

Progress in lipid emulsions as antidotes to reverse drug poisoning

1.
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009
2.
Department of Emergency Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Funds: This study was supported by the National Natural Science Foundation of China (No.82172184, No.81973266)

摘要

摘要: 脂肪乳因安全性高、适用范围广和起效时间短，在药物中毒解救领域具有广阔的应用前景。本文从部分临床病例报告出发，分析了脂肪乳在局麻类、抗心律失常类、精神类和有机磷酸酯类等多种药物中毒解救中的效果及脂肪乳可能带来的不良反应。同时对脂肪乳的解毒机制：如脂质池理论、机体代谢增强理论和强心作用等，进行了充分阐释。最后对脂肪乳疗法存在的问题提出了可能的解决方案，以期能加深对脂肪乳解毒疗法的了解，促进其在药物中毒临床解救中的合理应用。
- 脂肪乳 /
- 解毒剂 /
- 药物中毒 /
- 解毒机制 /
- 脂质池理论
Abstract: Due to their good safety, wide application scope and quick onset time, lipid emulsions are full of promise to reverse drug poisoning. In this review, a number of clinical case reports were summarized to analyze the detoxification effect of lipid emulsions on local anesthetic, antiarrhythmic, psychotropic and organophosphate poisoning, as well as the possible adverse reactions of lipid emulsions therapy.Meanwhile, the mechanisms underlying lipid emulsions therapy, such as lipid sink theory, enhanced body basal metabolism and positively affected cardiovascular function, were fully interpreted.Besides, a few potential solutions to the problems still existing in lipid emulsions therapy were proposed, in order to consolidate the understanding of lipid emulsions therapy and promote its rational application in reversing drug poisoning.
- lipid emulsion /
- antidote /
- drug poisoning /
- detoxification mechanism /
- lipid sink theory

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脂肪乳在药物中毒解救中的应用研究

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出版历程

Progress in lipid emulsions as antidotes to reverse drug poisoning

期刊类型引用(8)

其他类型引用(12)

计量

出版历程

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