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大黄素的药理作用机制研究进展

吴丛宇, 周悦, 上官璐茜, 杨雅妮, 王晶雅, 余俊河, 宫帅帅, 寇俊萍

吴丛宇, 周悦, 上官璐茜, 杨雅妮, 王晶雅, 余俊河, 宫帅帅, 寇俊萍. 大黄素的药理作用机制研究进展[J]. 中国药科大学学报, 2023, 54(5): 634-643. DOI: 10.11665/j.issn.1000-5048.2023052501
引用本文: 吴丛宇, 周悦, 上官璐茜, 杨雅妮, 王晶雅, 余俊河, 宫帅帅, 寇俊萍. 大黄素的药理作用机制研究进展[J]. 中国药科大学学报, 2023, 54(5): 634-643. DOI: 10.11665/j.issn.1000-5048.2023052501
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WU Congyu, ZHOU Yue, SHANGGUAN Luxi, YANG Yani, WANG Jingya, YU Junhe, GONG Shuaishuai, KOU Junping. Progress of research on the pharmacological effects and mechanisms of emodin[J]. Journal of China Pharmaceutical University, 2023, 54(5): 634-643. DOI: 10.11665/j.issn.1000-5048.2023052501
Citation: WU Congyu, ZHOU Yue, SHANGGUAN Luxi, YANG Yani, WANG Jingya, YU Junhe, GONG Shuaishuai, KOU Junping. Progress of research on the pharmacological effects and mechanisms of emodin[J]. Journal of China Pharmaceutical University, 2023, 54(5): 634-643. DOI: 10.11665/j.issn.1000-5048.2023052501
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大黄素的药理作用机制研究进展

  • 中国药科大学中药学院中药药理与中医药学系，江苏省中药评价与转化重点实验室，南京 211198

基金项目: 国家级大学生创新创业训练计划资助项目（No.202310316014Z）

Progress of research on the pharmacological effects and mechanisms of emodin

  • Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the National Innovation and Entrepreneurship Training Program for Undergraduate（No.202310316014Z）

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    摘要
  • 摘要: 大黄素作为一种羟基蒽醌类活性成分，在大黄、虎杖及何首乌等中药中含量丰富。现代药理研究表明，大黄素具有广泛药理活性，包括抗肿瘤、抗炎和免疫调节、抗菌和抗病毒、心肌保护、神经保护、肾脏保护、骨保护、抗纤维化等作用，药用价值高，具有广阔的应用前景。本文旨在总结近5年来发表于国内外期刊有关大黄素的药理活性和作用机制研究进展，重点介绍并总结大黄素在发挥药理作用过程中涉及的潜在靶点及重要分子信号通路，为大黄素的进一步开发和临床应用提供参考依据与线索。
    Abstract: As an active hydroxyanthraquinone ingredient, emodin is abundant in Chinese medicine herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum.Modern pharmacological studies have shown that emodin has a variety of pharmacological activities including anti-tumor, anti-inflammatory and immunoregulatory, antibacterial and anti-viral effects, myocardial protection, neuroprotection, renal protection, bone protection, antifibrosis and so on, which indicate its high medicinal value and broad application prospects.This article aims to summarize the progress in the pharmacological activity and mechanism of action of emodin published in domestic and international journals over the last 5 years and highlight the potential targets and molecular signaling pathways linked with emodin, so as to provide some clues and references for further development and clinical application of emodin.
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    • 参考文献(80)
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  • 收稿日期:  2023-05-24
  • 修回日期:  2023-10-17
  • 刊出日期:  2023-10-24

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