LI Wenhai, HOU Jinming, YOU Qidong. Synthesis and HIV-1 reverse transcriptase inhibitory activity of 3,4-disubstituted coumarin derivatives[J]. Journal of China Pharmaceutical University, 2013, 44(1): 28-34. DOI: 10.11665/j.issn.1000-5048.20130104
Citation:
LI Wenhai, HOU Jinming, YOU Qidong. Synthesis and HIV-1 reverse transcriptase inhibitory activity of 3,4-disubstituted coumarin derivatives[J]. Journal of China Pharmaceutical University, 2013, 44(1): 28-34. DOI: 10.11665/j.issn.1000-5048.20130104
LI Wenhai, HOU Jinming, YOU Qidong. Synthesis and HIV-1 reverse transcriptase inhibitory activity of 3,4-disubstituted coumarin derivatives[J]. Journal of China Pharmaceutical University, 2013, 44(1): 28-34. DOI: 10.11665/j.issn.1000-5048.20130104
Citation:
LI Wenhai, HOU Jinming, YOU Qidong. Synthesis and HIV-1 reverse transcriptase inhibitory activity of 3,4-disubstituted coumarin derivatives[J]. Journal of China Pharmaceutical University, 2013, 44(1): 28-34. DOI: 10.11665/j.issn.1000-5048.20130104
Benzo 6-membered heterocyclic compounds are important reverse transcriptase inhibitors.Active compounds reported in the literature have a hydrophobic benzene ring and an amide moiety connected with the benzene ring.Aiming at structural modification of amide part, a series of 3,4-disubstituted coumarin compounds were prepared.Their structures were confirmed by IR,MS,1H NMR and element analysis.The results of the preliminary pharmacological test showed that seven out of twenty-three compounds possessed diverse HIV-1 reverse transcriptase inhibitory activity.