• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
CHEN Jing, RAO Guangling, HUANG Jing, GE Liang, SHI Qin. Preparation of lyophilized HZ08 liposomes and the reversal of multidrug resistance in tumor[J]. Journal of China Pharmaceutical University, 2013, 44(2): 130-133. DOI: 10.11665/j.issn.1000-5048.20130206
Citation: CHEN Jing, RAO Guangling, HUANG Jing, GE Liang, SHI Qin. Preparation of lyophilized HZ08 liposomes and the reversal of multidrug resistance in tumor[J]. Journal of China Pharmaceutical University, 2013, 44(2): 130-133. DOI: 10.11665/j.issn.1000-5048.20130206
shu

Preparation of lyophilized HZ08 liposomes and the reversal of multidrug resistance in tumor

More Information
    Graphical Abstract
    • Abstract
  • HZ08 liposomes (HL) and lyophilized HZ08 liposomes (LHL) were prepared and characterized by encapsulation efficiency (EE),particle size (PS) and long term stability.The effect of LHL on reversal of adriamycin resistance was investigated by K562/A02 cell reversal of adriamycin resistance experiment.It was found that the PS and EE had no significant change after freeze-drying of HL.However,leakage rate of LHL (12.32%) was significantly lower than that of LHL (25.92%) after 12-weeks storage.The effect of LHL on the reversal of adriamycin resistance was investigated by K562/A02 cell reversal with different concentration LHL(10,3,1 μmol/L),and the reversal fold was 50.87,17.75 and 2.05,respectively.In 3 months,6 months and 12 months,LHL was sampled to determine the quality,and there was no obvious change during the storage.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]QIAN Qianqian, LI Guozhi, TIAN Hong, GAO Xiangdong. Design, preparation, and antitumor activity of fusion protein vaccine based on tumor antigen PBK[J]. Journal of China Pharmaceutical University, 2024, 55(5): 657-665. DOI: 10.11665/j.issn.1000-5048.2024030801
    [2]ZHOU Hongyou, GAO Xiangdong, YAO Wenbing, TIAN Hong. Screening of adjuvant for PD-L1 vaccine based on nitrated T cell epitope[J]. Journal of China Pharmaceutical University, 2024, 55(3): 397-403. DOI: 10.11665/j.issn.1000-5048.2023032801
    [3]LI Mengyuan, JIANG Xiaomeng, SUN Qinyi, GUO Wei. Research progress of CAR-T immunotherapy in solid tumors combined with new strategies[J]. Journal of China Pharmaceutical University, 2023, 54(4): 443-449. DOI: 10.11665/j.issn.1000-5048.2023030101
    [4]SHAO Shishuai, DUAN Shukang, TIAN Hong, YAO Wenbing, GAO Xiangdong. Design and antitumor activity of programmed cell death ligand 1 epitope peptide vaccine[J]. Journal of China Pharmaceutical University, 2023, 54(2): 245-254. DOI: 10.11665/j.issn.1000-5048.2023022803
    [5]WANG Zhenghao, GAO Yafeng, ZHANG Lianjun, LIU Chang. Research progress of T cell anti-tumor function regulated by endoplasmic reticulum stress[J]. Journal of China Pharmaceutical University, 2022, 53(5): 518-524. DOI: 10.11665/j.issn.1000-5048.20220502
    [6]YAO Zheng, LI Zihan, GAO Liming, HU Xing, CHEN Yan, PAN Wenqi, LI Qian. Advances of research on CAR-T cell immunotherapy for solid tumors[J]. Journal of China Pharmaceutical University, 2021, 52(4): 496-504. DOI: 10.11665/j.issn.1000-5048.20210413
    [7]XIA Xuefei, ZHANG Li, LUO Jianhua, YAO Wenbing, GAO Xiangdong, TIAN Hong. Design and antitumor activity of immune checkpoint B7-H3 epitope vaccine[J]. Journal of China Pharmaceutical University, 2021, 52(4): 472-479. DOI: 10.11665/j.issn.1000-5048.20210410
    [8]CHEN Hongmei, KANG Yanliang, LIU Li, YAO Wenbing, TIAN Hong. Effects of different immunogenic amino acids in PD-L1 vaccine on the differentiation of T cell subsets[J]. Journal of China Pharmaceutical University, 2020, 51(3): 349-356. DOI: 10.11665/j.issn.1000-5048.20200313
    [9]JIANG Liangliang, JIANG Tao, LUO Jianhua, YAO Wenbing, TIAN Hong. A novel human immune system mice model for assessing the immunogenicity of cancer vaccines[J]. Journal of China Pharmaceutical University, 2019, 50(6): 734-742. DOI: 10.11665/j.issn.1000-5048.20190615
    [10]SUN Zhan-yi, CAI Hui, HUANG Zhi-hua, SHI Lei, CHEN Yong-xiang, LI Yan-mei. Advances of glycopeptide-associated tumor vaccines[J]. Journal of China Pharmaceutical University, 2012, 43(2): 97-106.

Catalog

    Get Citation
    PDF
    XML
    Article views PDF downloads Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：365820

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return