• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
LEI Hui, TAN Jiani, LI Shaoping, LI Haitao, JI Hui. Turmeric oil induces human hepatoma cell apoptosis via mitochondrial pathway[J]. Journal of China Pharmaceutical University, 2013, 44(3): 263-266. DOI: 10.11665/j.issn.1000-5048.20130315
Citation: LEI Hui, TAN Jiani, LI Shaoping, LI Haitao, JI Hui. Turmeric oil induces human hepatoma cell apoptosis via mitochondrial pathway[J]. Journal of China Pharmaceutical University, 2013, 44(3): 263-266. DOI: 10.11665/j.issn.1000-5048.20130315

Turmeric oil induces human hepatoma cell apoptosis via mitochondrial pathway

More Information
  • To evaluate the anti-human hepatocellular carcinoma activity of turmeric oil(TO). Cell viability was assessed by MTT assay, cell apoptosis and mitochondrial membrane potential were measured by flow cytometry. The protein abundance of Bax, Bcl-2, caspase-3, caspase-9 and cytochrome C was analyzed by Western blot. The results demonstrated TO-induced apoptosis of Bel-7402 cells in a time- and dose- dependent manners. It was characterized by loss of mitochondrial membrane potential(ΔΨm)and enhanced Bax/Bcl-2 ratio. The release of cytochrome C from mitochondria and the activation of caspase-9 and -3 indicated that TO might induce apoptosis of Bel-7402 cells via mitochondrial-mediated pathway.
  • Related Articles

    [1]LI Hongxue, ZHANG Lei. Analysis of patent applications of heterocyclic compounds in China Pharmaceutical University 2010-2014[J]. Journal of China Pharmaceutical University, 2016, 47(2): 247-250. DOI: 10.11665/j.issn.1000-5048.20160220
    [2]MAO Dan. Patent analysis of pharmaceutical cocrystals technology in China[J]. Journal of China Pharmaceutical University, 2015, 46(4): 509-512. DOI: 10.11665/j.issn.1000-5048.20150421
    [3]WANG Jingjing, WANG Huiyan, ZHANG Lingling, XIAO Jing, HU Weiguo, ZHANG Caixia, ZHOU Jie. Technical analysis of low molecule weight heparins patents and R&D suggestions[J]. Journal of China Pharmaceutical University, 2015, 46(4): 504-508. DOI: 10.11665/j.issn.1000-5048.20150420
    [4]X-Ray Diffraction Fourier Fingerprint Pattern Analysis for Qingkailing Patent Medicine[J]. Journal of China Pharmaceutical University, 2004, (2): 41-43.
    [5]Study on Related Substances and Stability of Ceftazidime and its Preparation[J]. Journal of China Pharmaceutical University, 2002, (2): 35-38.
    [6]System Separation of Cyclosporin A Triple Therapeutic Drugs by Micellar Electrokinetic Capillary Chromatography and Evaluation of Optimal Method Ruggedness[J]. Journal of China Pharmaceutical University, 1999, (5): 373-376.
    [7]HPLC Analysis of Metoprolol and Its Metabolites in the Perfusates[J]. Journal of China Pharmaceutical University, 1997, (6): 31-35.
    [8]NMR Analysis of Bromocriptine Mesilate Tenoxicam[J]. Journal of China Pharmaceutical University, 1997, (5): 33-35.
    [9]Studies on the Synthesis and Analysis of Impurities and Decomposition Product of Ondansetron Hydrochlorid[J]. Journal of China Pharmaceutical University, 1997, (4): 8-10.
    [10]The Preparation and Analysis of New Sweetener L-Asp-D-Ala-OiPr[J]. Journal of China Pharmaceutical University, 1997, (2): 114-115.

Catalog

    Article views (1185) PDF downloads (1876) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return