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LI Linhu, CHEN Li, XIA Yufeng. Progress in the study of coumarin derivatives as antitumor agents[J]. Journal of China Pharmaceutical University, 2013, 44(4): 374-379. DOI: 10.11665/j.issn.1000-5048.20130417
Citation: LI Linhu, CHEN Li, XIA Yufeng. Progress in the study of coumarin derivatives as antitumor agents[J]. Journal of China Pharmaceutical University, 2013, 44(4): 374-379. DOI: 10.11665/j.issn.1000-5048.20130417

Progress in the study of coumarin derivatives as antitumor agents

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  • Coumarins are a class of compounds with multiple biological activities such as antitumor, anti-inflammatory, anti-virus, and anti-bacterial properties. The anti-tumor activity is of high selectivity and low toxicity, however, the clinical use of natural coumarins is often restricted by their less bioactivity, poorer water-solubility and lower bioavailability. Therefore, the structural modification and structure-activity relationship of coumarins have become a research hotspot. The recent progress in the studies of coumarin derivatives with antitumor activities is reviewed in this paper.
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