Physicochemical characterization of co-amorphous repaglinide-saccharin

The rotary solvent-evaporation method was successfully used to prepare the co-amorphous repaglinide-saccharin(REP-SAC)with molar ratios of 1 ∶1 and 2 ∶1, respectively. The co-amorphous solids were characte-rized by differential scanning calorimetry(DSC), infrared spectroscopy(FTIR)and powder X-ray diffraction(PXRD). The solubility and dissolution of co-amorphous REP-SAC in various buffers were tested and compared with crystalline REP, physical mixtures of REP and SAC with molar ratios of 1 ∶1 and 2 ∶1, and amorphous REP. It was observed that co-amorphous REP-SAC had significantly enhanced solubility and dissolution. Also, co-amorphous REP-SAC was proved to be maintained in amorphous state with similar chemical stability to crystalline REP.