• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
XU Meixia, SUN Minjie, ZHANG Can, PING Qineng. Preparation and evaluation of colon adhesive pellets of 5-amino salicylic acid[J]. Journal of China Pharmaceutical University, 2013, 44(5): 432-436. DOI: 10.11665/j.issn.1000-5048.20130509
Citation: XU Meixia, SUN Minjie, ZHANG Can, PING Qineng. Preparation and evaluation of colon adhesive pellets of 5-amino salicylic acid[J]. Journal of China Pharmaceutical University, 2013, 44(5): 432-436. DOI: 10.11665/j.issn.1000-5048.20130509

Preparation and evaluation of colon adhesive pellets of 5-amino salicylic acid

More Information
  • This study was to develop 5-aminosalicylic acid pellets preparation to achieve colon adhesive. 5-amino salicylic acid loaded pellet cores using Carbomer 940 and HPC as bioadhesive agents were prepared by extrusion spheronization. The maximum drug load, different forming agents and process parameters of the pellet cores were studied with the formability as an indicator. The bioadhesion effect of different proportions of two bioadhesive agents was investigated by in vitro adhesion experiments. The pellets core was coated with Surelease® as inner layer for waterproof and Eudragit® S100 as outer layer for pH control. The in vitro release of the 5-amino salicylic acid pellets was studied in media of different pH. The maximum drug load of the pellets was 70% and PH301 was the best forming agent. The weight ratio of Carbomer 940 to hydroxypropyl cellulose should be kept 1 ∶1 to achieve high bioadhesion. The amount of Surelease® was 16% to 20% and Eudragit® S100 was 28%. Dissolution profiles of coated pellets revealed no drug release in the artificial gastric fluid within 2 h and released less than 10% in pH 6. 0 phosphate buffer within 5 h, while the coated pellets dissolved quickly in pH 7. 4 colonic fluid with a good adhesion effect. This approach was successfully utilized in the preparation of 5-amino salicylic acid pellets with the good colonic adhesion.
  • Related Articles

    [1]SHI Min, YONG Qin, HE Yingna, HUANG Shiqin, ZHAO Xuan, YU Xian. Construction and in vivo evaluation of a thermosensitive hydrogel system loading with Pseudomonas aeruginosa DNA vaccine[J]. Journal of China Pharmaceutical University, 2021, 52(2): 186-194. DOI: 10.11665/j.issn.1000-5048.20210207
    [2]CHEN Ye, YIN Jun, YAO Wenbing, GAO Xiangdong. Advances of DNA-based nanomaterials in tumor therapy[J]. Journal of China Pharmaceutical University, 2020, 51(4): 406-417. DOI: 10.11665/j.issn.1000-5048.20200404
    [3]WANG Rui, WANG Yongmei, CAI Mingjun, KE Xuejia, WU Yue, CHONG Jun, CAO Rongyue. Pharmacological effects of anti-melanoma DC vaccine sensitized by fusion proteins of G3G6 and HST1[J]. Journal of China Pharmaceutical University, 2019, 50(2): 238-245. DOI: 10.11665/j.issn.1000-5048.20190216
    [4]HAN Xiu, QI Xiaole, WU Zhenghong. Advances in self-assemblied DNA nanocages as drug delivery systems[J]. Journal of China Pharmaceutical University, 2017, 48(6): 663-669. DOI: 10.11665/j.issn.1000-5048.20170605
    [5]ZHANG Zhiqing, WANG Fang, ZHOU Ting, ZHANG Guodong, WANG Xiufeng, LI Yunze. A DNA polyaptamer system as a targeted antitumor drug delivery[J]. Journal of China Pharmaceutical University, 2015, 46(4). DOI: 10.11665/j.issn.1000-5048.20150408
    [6]Formula optimization and transfection efficiency of polyethyleneimine/DNA complexes[J]. Journal of China Pharmaceutical University, 2010, 41(1): 40-44.
    [7]Study on the Flavonoids from Lonicera confusa DC.[J]. Journal of China Pharmaceutical University, 2004, (4): 9-12.
    [8]Applications of Au Nanoparticles Labeling Method in DNA-detection and the Technology of Genechip[J]. Journal of China Pharmaceutical University, 2003, (2): 88-93.
    [9]The Isoquinolones from Menispermum dauricum DC.[J]. Journal of China Pharmaceutical University, 2001, (2): 16-17.
    [10]Ptotoplast Transformation of Staphylococcal DNA[J]. Journal of China Pharmaceutical University, 1992, (4): 239-242.

Catalog

    Article views (1076) PDF downloads (1856) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return