• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
ZHOU Xiaojuan, WU Su, WANG Wei, JI Yibing. Sensitive quantification of levocetirizine dihydrochloride enantiomeric impurities by capillary electrophoresis[J]. Journal of China Pharmaceutical University, 2013, 44(5): 437-441. DOI: 10.11665/j.issn.1000-5048.20130510
Citation: ZHOU Xiaojuan, WU Su, WANG Wei, JI Yibing. Sensitive quantification of levocetirizine dihydrochloride enantiomeric impurities by capillary electrophoresis[J]. Journal of China Pharmaceutical University, 2013, 44(5): 437-441. DOI: 10.11665/j.issn.1000-5048.20130510

Sensitive quantification of levocetirizine dihydrochloride enantiomeric impurities by capillary electrophoresis

More Information
  • A capillary electrophoresis(CE)method was developed for the quantification of levocetirizine dihydrochloride enantiomeric impurities. Sulfobutyl ether-β-cyclodextrin(SBE-β-CD)and hydroxypropyl-β-cyclodextrin(HP-β-CD)were selected as chiral selectors. Parameters including concentration of chiral selectors, pH of buffer solution, concentration of background electrolyte, and voltage applied were optimized by orthogonal experiment design. The optimal condition obtained was a running buffer consisting of 40 mmol/L sodium dihydrogen phosphate, 85 mg/mL chiral selectors at pH 5. 5 and voltage of 20 kV. The LOD and LOQ were 2. 0 μg/mL and 5. 0 μg/mL for isomers of levocetirizine dihydrochloride, respectively. This method could be applied to test the enantiomeric impurities of drug substance and tablets of levocetirizine dihydrochloride. A factorial experiment was exployed to investigate the complex interaction between SBE-β-CD and HP-β-CD in the separation of cetirizine enantiomers. Results indicated that synergistic effect existed between SBE-β-CD and HP-β-CD, which was only reflected in the apparent mobility rather than in the resolution.
  • Related Articles

    [1]HUANG Shuzhen, WANG Guangji, XIE Yuan. Advances in molecular mechanisms of organelle interaction and their role in disease development[J]. Journal of China Pharmaceutical University, 2019, 50(4): 389-396. DOI: 10.11665/j.issn.1000-5048.20190402
    [2]ZHENG Mei, LIU Fulei, XUE Jingwei, LIU Wenyuan. Investigation of herb-drug interaction between Liuwei Dihuang Pills and nifedipine based on rat liver microsomes and HPLC fingerprints[J]. Journal of China Pharmaceutical University, 2018, 49(2): 195-201. DOI: 10.11665/j.issn.1000-5048.20180209
    [3]ZHANG Tianxing, HUANG Wei, HUANG Xueyu, LIAO Anping. Interaction of oleanolic acid and its derivatives with bovine serum albumin by spectrofluorimetry[J]. Journal of China Pharmaceutical University, 2017, 48(5): 572-576. DOI: 10.11665/j.issn.1000-5048.20170511
    [4]WANG Yuhao, ZHANG Xue, ZHOU Xiaoting, HE Hua, LIU Xiaoquan. Pharmacokinetic interaction between sunitinib and ramipril in rats[J]. Journal of China Pharmaceutical University, 2017, 48(1): 60-65. DOI: 10.11665/j.issn.1000-5048.20170109
    [5]ZENG Yu, JI Yibing. Study of interaction between bovine serum albumin and nefopam enantiomers with affinity capillary monolith[J]. Journal of China Pharmaceutical University, 2016, 47(1): 66-72. DOI: 10.11665/j.issn.1000-5048.20160109
    [6]CHEN Lei, YANG Ping, JI Yibing. Chiral separation of esomeprazole and its enantiomer by affinity capillary electrophoresis[J]. Journal of China Pharmaceutical University, 2014, 45(4): 444-449. DOI: 10.11665/j.issn.1000-5048.20140411
    [7]CHENG Yu, HE Hua, CHEN Yuan-cheng, HUANG Li-hua, SI Qian, LIU Xiao-quan. Effects of content variation of water-soluble components in Dansheninjection on homocysteine metabolism in rats[J]. Journal of China Pharmaceutical University, 2011, 42(3): 255-261.
    [8]Interactions of folic acid and deoxycholic acid with bovine serum albumin as well as the effects of coexisting paclitaxel[J]. Journal of China Pharmaceutical University, 2010, 41(3): 253-258.
    [9]Metabolic Interaction of Cinildipine with Some Co-administrated Drugs in Human Liver Microsomes[J]. Journal of China Pharmaceutical University, 2004, (6): 43-46.
    [10]Studies on the Reaction Between Levofloxacin and Bovine Serum Albumin[J]. Journal of China Pharmaceutical University, 2004, (5): 70-73.

Catalog

    Article views (1193) PDF downloads (1971) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return